Head and Neck Cancer

Why trials studying Head and Neck Cancer stopped, in this sample of ClinicalTrials.gov.

37 stopped trials with a clear reason; 76% ended for non-scientific reasons.

Trials

• Decitabine and Nivolumab in Participants With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck
  NCT07216833 · WITHDRAWN · logistics pi
  “PI leaving the institution”
• DOLPHIN-VIVO: Diagnosis Of LymPHoma IN Vivo (In Vivo Phase)
  NCT05010369 · TERMINATED · funding business
  “Funding extension not granted”
• A Study to Test Different Doses of BI 765049 Alone and in Combination With Ezabenlimab in Asian People With Advanced Cancer (Solid Tumours) Positive for B7-H6
  NCT06091930 · TERMINATED · funding business
  “Sponsor decision”
• Role of Pharyngeal High Resolution Manometry and Impedance in Swallow Function of Head and Neck Cancer Patients
  NCT03372148 · WITHDRAWN · logistics pi
  “Study withdrawn by PI”
• Study of ALE.C04 in Patients With Head and Neck Cancer
  NCT06054477 · TERMINATED · funding business
  “Reprioritization of Trial”
• Study of BDC-3042 as Single Agent and in Combination With Cemiplimab in Patients With Advanced Malignancies
  NCT06052852 · TERMINATED · funding business
  “Sponsor decision”
• Venlafaxine for the Prevention of Depression in Patients With Head and Neck Cancer
  NCT05724849 · WITHDRAWN · funding business
  “Issues with funding”
• Online Peri-operative Education Program for Patients Undergoing Major Head & Neck Surgery
  NCT05954676 · WITHDRAWN · slow accrual
  “Zero accruals”
• Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION)
  NCT05386550 · TERMINATED · funding business
  “The study was terminated by sponsor as the development program was discontinued due to outcome of phase III Trilynx study.”
• FT536 Monotherapy and in Combination With Monoclonal Antibodies in Advanced Solid Tumors
  NCT05395052 · TERMINATED · funding business
  “This study was terminated by the Sponsor.”
• Enoblituzumab Plus Retifanlimab or Tebotelimab in Head and Neck Cancer
  NCT04634825 · TERMINATED · safety
  “Based on internal review of safety data”
• A Phase 1a/1b FIH Study of PY159 and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors
  NCT04682431 · TERMINATED · funding business
  “Sponsor business decision.”
• Long-term, Non-interventional, Observational Study Following Treatment With Fate Therapeutics FT500 Cellular Immunotherapy
  NCT04106167 · TERMINATED · funding business
  “This study was terminated by the Sponsor.”
• Stellate Ganglion Block in Head and Neck Cancer Surgery
  NCT03714906 · TERMINATED · futility
  “Slow accrual, lack of benefit between intervention and control arms on interim analysis”
• Trial of Ibrutinib Combined With Nivolumab or Cetuximab to Treat Recurrent/Metastatic HNSCC
  NCT03646461 · TERMINATED · funding business
  “Lack of scientific process of cancer-related clinical intervention”
• A Phase 2 Study of NIR178 in Combination With PDR001 in Patients With Solid Tumors and Non-Hodgkin Lymphoma
  NCT03207867 · TERMINATED · funding business
  “Sponsor decision”
• A Study of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC in Patients With Solid Tumors or Lymphoma (Toca 6)
  NCT02576665 · TERMINATED · funding business
  “Sponsor decision”
• Measuring the Effect of Radiation Therapy on Patient Activity Levels
  NCT02694380 · TERMINATED · slow accrual
  “Low accrual”
• Safety Study of HPV DNA Vaccine to Treat Head and Neck Cancer Patients
  NCT01493154 · TERMINATED · funding business
  “Study Funding Terminated”
• Feasibility Study to Estimate Number of Patients With Precancerous Areas in Their Airways and the Response to Gefitinib
  NCT01405846 · TERMINATED · futility
  “Futility”
• Magnetic Resonance Imaging (MRI) in the Assessment of Head and Neck Squamous Cell Carcinoma (HNSCC) Response
  NCT00994201 · TERMINATED · slow accrual
  “Study never accrued sufficient subjects”
• Photodynamic Therapy Using HPPH in Treating Patients With Recurrent Dysplasia, Carcinoma in Situ, or Stage I Oral Cavity Cancer
  NCT00670397 · TERMINATED · safety
  “safety issues”
• A Pilot Study of Induction Chemotherapy Followed by Surgery for Locally Advanced Resectable Head and Neck Cancer
  NCT01111942 · TERMINATED · slow accrual
  “lack of enrollment”
• A Study of CP-751,871 in Patients With Recurrent Squamous Head and Neck Carcinoma
  NCT00872404 · TERMINATED · futility
  “lack of efficacy”
• S0716 Vandetanib and Docetaxel in Treating Patients With Advanced Solid Tumors
  NCT00937417 · WITHDRAWN · other
  “Withdrawn because SWOG no longer pursuing this study at this time”
• A Study of Palifermin for the Reduction of Oral Mucositis in Subjects With Locally Advanced Head and Neck Cancer Receiving Postoperative Radiotherapy
  NCT00540332 · WITHDRAWN · funding business
  “The 20070201 study was terminated based on evaluation of Palifermin solid tumor data.”
• Lapatinib and Radiation for Stage III-IV Head and Neck Cancer Patients Who Cannot Tolerate Concurrent Chemotherapy
  NCT00490061 · TERMINATED · slow accrual
  “Poor accrual.”
• Amifostine With IMRT for Submandibular and Sublingual Salivary Sparing During Head and Neck Cancer Treatment
  NCT00409331 · TERMINATED · logistics pi
  “Study terminated by Principal Investigator; no patients completed study.”
• Pilot Study of (61)CuATSM-PET Imaging in Cancer Patients
  NCT00585117 · TERMINATED · funding business
  “change in imaging priorities”
• Zalutumumab in Combination With Chemotherapy and Radiotherapy in Head and Neck Cancer
  NCT00401401 · TERMINATED · safety
  “MTD was established and patients completed 16 months safety f-up and response assessments. It is considered of limited value to follow patients for 3 years.”
• Pemetrexed and Gemcitabine in Patients With Advanced Head and Neck Cancer
  NCT00394147 · TERMINATED · futility
  “stopped for lack of efficacy”
• Electroacupuncture in Treating Chronic Dry Mouth Caused By Radiation Therapy in Patients With Head and Neck Cancer
  NCT00623129 · TERMINATED · slow accrual
  “Slow accrual; did not meet accrual goal”
• Post-operative Radiotherapy With Cisplatin Alone or in Combination With Iressa in Upper Aerodigestive Tract Carcinomas
  NCT00169221 · TERMINATED · safety
  “Toxicity in an independent study IMEX. The trial was subsequently terminated (54 pts instead of 140) despite safety analyses showing no excess of toxicity”
• Adjuvant Chemoradiation With Weekly Oxaliplatin in Resected Head and Neck Cancer
  NCT00256308 · TERMINATED · slow accrual
  “Halted prematurely due to slow accrual”
• Irinotecan in Treating Patients With Metastatic or Inoperable Thyroid Cancer
  NCT00100828 · TERMINATED · slow accrual
  “Closed due to early stopping rule”
• S0011, Gene Therapy & Surgery Followed by Chemo & RT in Newly Diagnosed Cancer of the Mouth or Throat
  NCT00017173 · TERMINATED · slow accrual
  “Terminated for poor accrual.”
• Chemotherapy Plus Radiation Therapy With or Without Amifostine in Treating Patients With Locally Advanced Cancer of the Nasopharynx
  NCT00025298 · TERMINATED · slow accrual
  “low accrual”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.