Autopsy report · NCT03542812

L-citrulline and Pulmonary Hypertension Associated With Bronchopulmonary Dysplasia

“The study stopped enrollment prior to the initially projected 18 subjects per phase due to lack of funding to continue to recertify the drug and because an adequate number of subjects were enrolled for each phase to analyze pharmacokinetics.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 year 3 months before it started.
• Ran for about 3 years 1 month before it stopped.
• 16 participants enrolled.
• Results were posted on the registry 1 year 8 months after it ended.

Vital statistics

Status

Terminated

Phase

Early Phase 1

Sponsor

University of Utah

Sponsor type

University, hospital or other

Conditions

Infant,Premature; Bronchopulmonary Dysplasia; Pulmonary Hypertension

Interventions

L-Citrulline

Participants

16

Sites

1

Countries

United States

Trials that died the same way

• A Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease
  “Study stopped due to business reasons, following full enrollment of the first dose cohort.” (73% match in meaning)
• The Role of Osteopathic Manipulative Medicine in Recovery From Concussions
  “Due to lower than anticipated enrollment number, this study was stopped.” (72% match in meaning)
• A Phase 2 Study of Intravitreal AVD-104 in Diabetic Macular Edema
  “The trial was stopped early due to insufficient study drug supply and study funding constraints” (71% match in meaning)
• Omission of Surgery in Clinically Low-risk HER2positive Breast Cancer With High HER2 Addiction and a Complete Response Following Standard Anti-HER2-based Neoadjuvant Therapy
  “The study was prematurely halted primarily due to low patient accrual. Despite efforts to optimize recruitment, the enrollment rate remained insufficient to meet the predefined targets, and continuation was deemed unfeasible” (70% match in meaning)
• The Effect of Buprenorphine Continuation for Patients With Opioid Use Disorder
  “This study was halted prior to accumulating the full number of participants due to difficulty in recruiting study subjects.” (70% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.