Autopsy report · NCT03368664

A Study to Evaluate Efficacy, Safety, and Tolerability of Alemtuzumab in Pediatric Patients With RRMS With Disease Activity on Prior DMT

“Enrolment formally closed earlier than planned due to recruitment challenges.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 7 years 11 months before it stopped.
• 16 participants enrolled.
• Results were posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Genzyme, a Sanofi Company

Sponsor type

Industry

Conditions

Multiple Sclerosis

Interventions

Alemtuzumab GZ402673; Glatiramer acetate; Beta-Interferon; Methylprednisolone; Ranitidine; Ceterizine

Participants

16

Sites

13

Countries

France, Italy, Poland, Russia, Turkey (Türkiye), United Kingdom

Trials that died the same way

• Iressa vs Placebo as Maintenance Therapy in Locally Advanced NSCLC
  “Closed due to insufficient recruitment” (71% match in meaning)
• Comparison of DSCT With IB-IVUS and Angiography in the Assessment of Coronary Artery Disease
  “Subject recruitment was slow, so enrollment has been closed.” (66% match in meaning)
• Prospective Study of Non-operative Management of SBO Without Nasogastric Tube Placement
  “Study was closed due to lack of personnel for recruitment/enrollment purposes.” (66% match in meaning)
• Study of Heart Failure Hospitalizations After Aquapheresis Therapy Compared to Intravenous (IV) Diuretic Treatment
  “Closed due to patient recruitment challenges. No interim analyses were completed; study closure was not related to any concerns about safety or futility.” (65% match in meaning)
• Satisfaction of Patients With Amyotrophic Lateral Sclerosis Regarding Home Assisted Teleconsultation
  “The study was terminated early due to insufficient recruitment despite mitigation measures, as enrolment rates could not meet protocol objectives. Academic thesis scheduling constraints also contributed. No safety concerns were identified.” (64% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.