Autopsy report · NCT03366220

Resuscitation With Plasma in Surgical and Trauma Patients With Septic Shock

“The study was halted early due to low patient accrual secondary to COVID-19 and significant heterogeneity in clinical manifestations of sepsis precluding enrollment.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 4 months before it started.
• Ran for about 1 year 7 months before it stopped.
• 16 participants enrolled.
• Results were posted on the registry 2 years 6 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

The University of Texas Health Science Center, Houston

Sponsor type

University, hospital or other

Conditions

Septic Shock

Interventions

Plasma; Balanced crystalloids

Participants

16

Sites

1

Countries

United States

Trials that died the same way

• Intensive Care Associated Complications and Outcome of Acute Respiratory Distress Syndrome Due to COVID-19
  “Number of Covid-19 cases who need intensive care have greatly reduced, it is very difficult to find eligible patients for the study” (68% match in meaning)
• The Efficacy of Denosumab in Incomplete Patients Spinal Cord Injury
  “Study ended early due to COVID-19” (66% match in meaning)
• PALS for Nutrition Education
  “COVID-19 paused study temporarily due to no clinical encounters” (66% match in meaning)
• Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms
  “A total of 21 patients were enrolled in the study resulting in 97 total collected specimen time points. Patient recruitment was halted due to greatly decreased numbers of patient hospitalizations for Covid-19.” (65% match in meaning)
• A Study to Learn About the Medicine Called Nirmatrelvir Used in Combination With Ritonavir in People With Weakened Immune Systems or at Increased Risk for Poor Outcomes Who Are Hospitalized Due to Severe COVID-19
  “Termination due to challenges related to the operational feasibility of the study, taking into account the current epidemiology and declining hospitalization rates for severe COVID-19.” (65% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.