Autopsy report · NCT03150056

Dose Escalation and Dose Expansion Study of GSK525762 in Combination With Androgen Deprivation Therapy in Participants With Castrate-resistant Prostate Cancer

“This study has been terminated due to meeting protocol defined futility.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 months before it started.
• Ran for about 3 years 11 months before it stopped.
• 73 participants enrolled.
• Results were posted on the registry 2 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

GlaxoSmithKline

Sponsor type

Industry

Conditions

Solid Tumours

Interventions

GSK525762; Abiraterone; Enzalutamide; Prednisone

Participants

73

Sites

20

Countries

Australia, Spain, United Kingdom, United States

Trials that died the same way

• An Adaptive Phase II Study to Evaluate the Efficacy, Pharmacodynamics, Safety and Tolerability of GSK2586184
  “This study met a protocol defined futility criterion and will be terminated following completion of the Follow Up Visit on the last subject randomised.” (76% match in meaning)
• Minocycline for the Treatment of Decreased Mental Function in HIV-Infected Adults
  “This study was terminated early due to futility.” (75% match in meaning)
• Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM)
  “This trial was terminated following a futility analysis confirming futility of continuing the study” (74% match in meaning)
• Nilotinib With Chemotherapy for the Treatment of Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
  “The study was terminated due to excessive toxicity and low compliance to the protocol scheme.” (74% match in meaning)
• Trial to Evaluate UltraSound in the Treatment of Tibial Fractures
  “Study was terminated due to futility” (74% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.