GlaxoSmithKline

Why trials sponsored by GlaxoSmithKline stopped, in this sample of ClinicalTrials.gov.

39 stopped trials with a clear reason; 64% ended for non-scientific reasons.

Where it ranks

• #2 of 90 sponsors by share of trials stopped for: futility (23%).

Among ranked sponsors in this sample. Shares of stopped trials, not failure rates. See all scorecards.

Trials

• Long-Term Study (AtDvance) to Evaluate GSK1070806 in Atopic Dermatitis.
  NCT06447506 · TERMINATED · funding business
  “Sponsor decision to early terminate the study following the termination of the parent study (NCT05999799), which met pre-defined futility criterion for efficacy. No safety concerns were identified.”
• A Dose-Finding Study to Evaluate the Efficacy and Safety of GSK3858279 in Adults With Knee Osteoarthritis (OA) Pain
  NCT05838742 · TERMINATED · futility
  “The study met futility criteria at pre-planned interim analysis, showing no clinical efficacy of the investigational drug. Based on the lack of efficacy at the interim data review, the sponsor decided to terminate the study.”
• A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Oral GSK4172239D Compared With Placebo in Sickle Cell Disease Participants Aged 18 to 50 Years
  NCT05660265 · TERMINATED · funding business
  “Sponsor decision to terminate the study due to strategic business consideration and not related to safety.”
• A Study of Belantamab Mafodotin in Multiple Myeloma Participants With Normal and Impaired Hepatic Function
  NCT04398680 · WITHDRAWN · funding business
  “Sponsor Decision”
• Efficacy Comparison of Dostarlimab Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy in Participants With Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC)
  NCT04581824 · TERMINATED · funding business
  “Trial terminated by GSK for strategic reasons, after all participants completed treatment. This decision was not based on a safety concern”
• Effects of Intravenous GSK3858279 on a Battery of Evoked Pain Tests in Healthy Volunteers
  NCT04114656 · TERMINATED · futility
  “This study was terminated due to meeting protocol defined futility.”
• Platform Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With aOX40 (GSK3174998) in Participants With RRMM
  NCT06160609 · TERMINATED · futility
  “The study was terminated due to lack of efficacy.”
• Safety, Tolerability and Pharmacokinetics (PKs) Investigation of GSK3186899 in Healthy Subjects
  NCT03874234 · TERMINATED · funding business
  “The trial was terminated early following strategic review after emergence of nonclinical data with a non-GlaxoSmithKline asset.”
• A Safety and Efficacy Study of Intranasal GSK2245035 in Adults With Allergic Asthma
  NCT03707678 · WITHDRAWN · funding business
  “After careful review of new data on GSK2245035, GlaxoSmithKline has decided to cancel this study.”
• First Time in Humans (FTIH) Study of GSK3368715 in Participants With Solid Tumors and Diffuse Large B-cell Lymphoma (DLBCL)
  NCT03666988 · TERMINATED · futility
  “Overall benefit-risk profile did not support continuation of the study”
• Effects of GSK2798745 on Alveolar Barrier Disruption in a Segmental Lipopolysaccharide (LPS) Challenge Model
  NCT03511105 · TERMINATED · futility
  “Study terminated due to low probability of achieving a positive outcome on the primary endpoint.”
• GSK2894512 Vehicle-Controlled Study for Adult Plaque Psoriasis
  NCT03202004 · WITHDRAWN · funding business
  “The decision not to progress the planned Phase 3 studies is a business decision based on the need to prioritise and focus resources within GSK.”
• Safety, Clinical Activity, Pharmacokinetics (PK) and Pharmacodynamics Study of GSK2879552, Alone or With Azacitidine, in Subjects With High Risk Myelodysplastic Syndromes (MDS)
  NCT02929498 · TERMINATED · safety
  “The risk benefit in the study population does not favor continuation of the study”
• Comparison of Inhaled Oxytocin (IH) With Intramuscular (IM) Oxytocin in Pregnant Women and With Intravenous (IV) Oxytocin in Healthy Non-pregnant Women
  NCT02999100 · TERMINATED · other
  “Inability to reliably measure plasma oxytocin levels during third stage labour, regardless of administration method (intramuscular or inhaled).”
• Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Influenza Vaccine(s) GSK3277510A and GSK3277509A in Adults 18 to 60 Years of Age
  NCT02177734 · WITHDRAWN · funding business
  “The study was cancelled for scientifically legitimate reasons not related to safety or efficacy of the vaccine.”
• Clinical Efficacy of Fluoride Toothpastes Using an In Situ Caries Model
  NCT02436473 · WITHDRAWN · slow accrual
  “This study was cancelled. No subjects were enrolled and no data has been collected”
• A Randomized Study Comparing the Efficacy and Safety of Retosiban Versus Atosiban for Women in Spontaneous Preterm Labour
  NCT02292771 · TERMINATED · slow accrual
  “The study was stopped due to the feasibility of recruiting the study in a timely manner”
• Evaluation of Pazopanib on Bleeding in Subjects With Hereditary Haemorrhagic Telangiectasia
  NCT02204371 · TERMINATED · funding business
  “The study was terminated as the asset was sold to another company who decided not to pursue this indication with this drug.”
• A Study to Evaluate the Effect of GSK1322322 on Cardiac Conduction as Assessed by 12-lead Electrocardiogram in Healthy Volunteers
  NCT01803399 · WITHDRAWN · safety
  “Emerging GSK1322322 pre-clinical data ID'd potentially reactive metabolites previously not seen that changed the risk: benefit profile and led to a termination”
• Study to Evaluate Fractional Collagen Synthesis Within Keloid Scars and Identify Biomarkers of Keloid Scars
  NCT01978301 · TERMINATED · logistics pi
  “Temporary hold on recruitment during staff changes at the site”
• A Study to Evaluate Foretinib in Subjects With Non-Small-Cell Lung Cancer
  NCT02034097 · WITHDRAWN · funding business
  “GSK has decided to terminate the Product Development of foretinib and conclude our Development Agreement with Exelixis”
• GSK2647544 RD, DDI in Healthy Young and Elderly Volunteers
  NCT01978327 · TERMINATED · futility
  “Given the strength of CYP3A4 inhibition observed in Cohort 1, there is no rationale to investigate higher doses of GSK2647544 in the following two cohorts”
• An Open Study to Evaluate Whether Pack Size Affects Compliance of Metformin Treatment in Subjects With Type II Diabetes
  NCT01817777 · TERMINATED · slow accrual
  “It's no longer feasible to continue to recruit patients into the study as severe recruitment difficulties have been experienced since the study start”
• Post-marketing Surveillance of GSK Biologicals' Cervarix™ When Administered to Healthy Females in Sri Lanka
  NCT01551537 · WITHDRAWN · regulatory
  “Lack of clarity regarding the PMS study requirement from the RA and Ethics committee hence it was concluded GSK will submit local PSURs”
• A Study to Investigate Belimumab for the Treatment of Chronic Immune Thrombocytopenia.
  NCT01440361 · WITHDRAWN · other
  “This study was Cancelled Before Active”
• A Study to Investigate the Efficacy and Safety of GSK1605786 for Treatment of Patients With Active Ulcerative Colitis
  NCT01658605 · WITHDRAWN · funding business
  “Study CCX115383 has been terminated prior to enrolment of any patients. A decision was made by GSK to delay pursuit of this indication as the biology evolves.”
• Crossover Study to Evaluate the Comparative Bioavailability of Two Fixed Dose Combination Tablet Formulations of Extended Release Metformin and Extended Release Glimepiride in Health Volunteers
  NCT01725672 · TERMINATED · regulatory
  “Due to changes in EMA guidelines on modified release dosage forms (Feb 2013; EMA/CHMP/EWP/280/96). The Part B formulation would not meet the new guidelines.”
• 12 Week Patient Study in Neovascular Age-related Macular Degeneration (AMD)
  NCT01362348 · TERMINATED · futility
  “Lack of efficacy identified during a preliminary analysis”
• Open-Label Extension Study of GSK1605786A
  NCT01318993 · TERMINATED · futility
  “This study was terminated due to the lack of efficacy of GSK1605786A in Crohn's disease based on the results of Study CCX114151.”
• Trial to Evaluate Safety and Immunogenicity of GSK Biologicals' Influenza Vaccine GSK2584786A in Healthy Children
  NCT01195779 · TERMINATED · logistics pi
  “The study was terminated for logistic reasons not related to safety or efficacy of the vaccine.”
• Prospective Observational Study of Concomitant Allergic Rhinitis Treatment Patterns Among Patients Starting on Fluticasone Furoate Nasal Spray in a Retail Pharmacy Setting
  NCT01337323 · TERMINATED · slow accrual
  “Insufficient number of patient records met inclusion criteria”
• Safety, Pharmacodynamics and Pharmacokinetics of GSK2136525 Repeat Dose in Rheumatoid Arthritis
  NCT01077531 · TERMINATED · safety
  “The risk-benefit ratio for patients has changed since we initiated the study, and that the study in its current form cannot be justified”
• Study of a Birth Dose of GlaxoSmithKline Biologicals' 251154 Vaccine
  NCT01110044 · WITHDRAWN · funding business
  “Study was cancelled before enrolment for reasons not related to vaccine safety or efficacy.”
• Paracetamol With Caffeine to Treat Episodic Tension Type Headache
  NCT01755702 · TERMINATED · slow accrual
  “Study was terminated due to unforeseen difficulties with subject recruitment. No safety issues were identified in the study with this new formulation.”
• Study to Assess the Safety of a New GSK Biologicals' GSK2231395A Candidate Vaccine
  NCT00849069 · TERMINATED · logistics pi
  “The study has been stopped for logistic reasons not related to the safety or efficacy of the vaccine.”
• Clinical Evaluation of BRL29060A (Paroxetine Hydrochloride Hydrate) in Posttraumatic Stress Disorder (PTSD)
  NCT00557622 · TERMINATED · slow accrual
  “difficulty in achieving target enrollment numbers”
• Pharmacoeconomic Consequences Of Analgesia in the Intensive Care Unit (ICU)
  NCT00436345 · TERMINATED · slow accrual
  “recruitment issues”
• GSK1572932A Antigen-Specific Cancer Immunotherapeutic as Adjuvant Therapy in Patients With Non-Small Cell Lung Cancer
  NCT00480025 · TERMINATED · futility
  “The study was terminated following assessment of the lack of efficacy of the study product by the Independent Data monitoring Committee for the study.”
• Effects Of Rosiglitazone (Extended Release Tablets) On Cerebral Glucose Utilisation And Cognition Alzheimers Disease
  NCT00334568 · TERMINATED · slow accrual
  “Slow recruitment”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.