Autopsy report · NCT02749292

Maintenance of ANCA Vasculitis Remission by Intermittent Rituximab Dosing

“Due to the coronavirus disease 2019 (COVID-19) pandemic and the deleterious impact of rituximab on vaccination efficacy, the trial was concluded before reaching the target enrollment of 200.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 3 months before it started.
• Ran for about 5 years 8 months before it stopped.
• 115 participants enrolled.
• Results were posted on the registry 1 year 6 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 4

Sponsor

Massachusetts General Hospital

Sponsor type

University, hospital or other

Conditions

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Interventions

Rituximab

Participants

115

Sites

1

Countries

United States

Trials that died the same way

• Pedicle Osteotomy for Stenosis Trial
  “In light of the ongoing COVID-19 pandemic and its impact on clinical trials” (64% match in meaning)
• Use of a Rapid Diagnostic Test for Antibiotic De-escalation in Severe Community Acquired Pneumonia
  “COVID pandemic precluded trial initiation. No longer clinical equipoise” (62% match in meaning)
• A Study to Assess the Therapeutic Effect and Safety of Adjunctive AKST4290 in Subjects With Bullous Pemphigoid
  “The study was prematurely terminated by the Sponsor due to operational challenges stemming from the coronavirus disease 2019 (COVID-19) pandemic, treatment limitations, rarity of the disease, and drug supply considerations.” (61% match in meaning)
• Platelet Transfusion in Sepsis Trial
  “COVID-19 trials gained priority” (60% match in meaning)
• A Phase I Clinical Study for Evaluating the Safety and Efficacy of MASCT-I in Patients With Advanced Solid Tumors
  “The study was terminated early due to the COVID-19 pandemic and sponsor's funding constraints, based on promising preliminary safety and efficacy data.” (59% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.