Autopsy report · NCT02698865

The MONOVISC Hip Osteoarthritis Study

“The results of the interim analysis indicate the futility criterion have been met, therefore enrollment was terminated.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 months after it had already started.
• Ran for about 3 years 6 months before it stopped.
• 220 participants enrolled.
• Results were posted on the registry 8 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

DePuy Mitek

Sponsor type

Industry

Conditions

Osteoarthritis of the Hip

Interventions

MONOVISC; Saline

Participants

220

Sites

27

Countries

United States

Trials that died the same way

• CONvalescent Plasma for Hospitalized Adults With COVID-19 Respiratory Illness (CONCOR-1)
  “Study was terminated after the planned interim analysis as the pre-defined futility threshold was met” (77% match in meaning)
• Efficacy Study of Dasatinib in Locally Advanced Triple-Negative Breast Cancer Patients
  “terminated due to futility after interim analysis” (75% match in meaning)
• Plasmalyte Versus Saline in Trauma Patients
  “Premature termination due to futility following interim analysis” (75% match in meaning)
• Study Evaluating PPM-204 In Subjects With Type 2 Diabetes
  “Study terminated as a result of interim analysis not meeting predetermined criteria.” (74% match in meaning)
• Study of Maternal Hepatitis C Infection and Influenza Vaccination in Pregnancy
  “Terminated due to lack of enrollment” (72% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.