Autopsy report · NCT00637468

EAGLE - Multicenter Study of the European Assessment Group for Lysis in the Eye

“Due to results of conditional power analysis performed at the first interim analysis and due to observed spectrum of adverse events.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 5 years 6 months after it had already started.
• 84 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

University Hospital Freiburg

Sponsor type

University, hospital or other

Conditions

Retinal Artery Occlusion; Fibrinolysis; Visual Acuity; Stroke; Hemodilution

Interventions

Intravenous injection of heparin; Intravenous injection of acetazolamide; Local intra-arterial fibrinolysis; Globe massage; Topical use of beta-blocker; Isovolaemic haemodilution

Participants

84

Sites

21

Countries

Austria, Germany, Switzerland

Trials that died the same way

• In-exsufflator Cough Assist Device in Patients With Symptomatic Bronchiectasis
  “interim analysis indicates statistical futility for primary outcomes” (61% match in meaning)
• ICVT in HPV-induced Genital Lesions of Immunocompromised and Immunocompetent Patients
  “Lack of effect in interim analysis” (60% match in meaning)
• Randomized, Multi-center, Open-label, Study of PR104 Versus PR104/Docetaxel in Non-Small Cell Lung Cancer (NSCLC)
  “Interim analysis indicated low probability of clinically significant result” (60% match in meaning)
• Stellate Ganglion Block in Head and Neck Cancer Surgery
  “Slow accrual, lack of benefit between intervention and control arms on interim analysis” (59% match in meaning)
• Impact of an Immune Modulator Dimethyl Fumarate on Acute Ischemic Stroke
  “The interim analysis of another associated study is not very effective” (59% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.