Stroke

Why trials studying Stroke stopped, in this sample of ClinicalTrials.gov.

53 stopped trials with a clear reason; 89% ended for non-scientific reasons.

Reason	Trials	Share
slow accrual	19	36%
funding business	14	26%
logistics pi	13	25%
other	3	6%
futility	2	4%
regulatory	1	2%
safety	1	2%

Trials

Evaluation of Sensorimotor Ankle Impairments in Chronic Stroke
NCT06410989 · SUSPENDED · logistics pi
“The study personnel left the institution and no alternative funding could be secured to implement the study”
New Model of Stroke Education
NCT05614882 · WITHDRAWN · funding business
“Lack of funding”
PET/MR in Post Stroke Cardiac Inflammation Study
NCT05791617 · TERMINATED · slow accrual
“Study terminated prematurely due to recruitment challenges.”
Iron Chelation in the Prevention of Secondary Degeneration After Stroke
NCT05111821 · TERMINATED · other
“Recent publications have raised questions about the validity of the research hypothesis, potentially altering the anticipated benefit-risk balance. Furthermore, recruitment and patient adherence to the protocol have proven insufficient.”
Window of Trainability in Relation to Surgical Correction of Foot Deformity
NCT05279222 · WITHDRAWN · slow accrual
“No participants were enrolled in the study within an inclusion period of 8 months”
A Coach-Guided Online Acceptance and Commitment Therapy (ACT) Intervention for Stroke Survivors
NCT05097040 · WITHDRAWN · logistics pi
“The research team decided not to implement this study.”
External Validation of Two Prediction Models for Independent Gait After Stroke
NCT05039047 · TERMINATED · slow accrual
“Change position of PI, no replacement available, therefore unable to continue recruitment - all enrolled patients finished the study according to plan”
Gene-guided Warfarin for Anticoagulation Therapy
NCT04482842 · WITHDRAWN · slow accrual
“No participants enrolled”
NOAC Portuguese Real World Study
NCT04808934 · WITHDRAWN · funding business
“Withdrawn due to COVID19 pandemic. Several delays affected this study, therefore company decided to not conduct the study. It was cancelled prior to any enrollment.”
HEAlth Dialogues for Patients With Mental Illness in Primary Care
NCT05181254 · TERMINATED · funding business
“Lack of funding.”
A Pilot Study of a Strategy and Computer-based Intervention to Enhance Daily Cognitive Functioning After Stroke
NCT04098835 · TERMINATED · slow accrual
“slow enrollment”
Effect of Local Pressure on Muscle Activity and General Relaxation in Persons With Hypertonia Following Stroke
NCT04188769 · WITHDRAWN · logistics pi
“lack of time”
The Effect of Optic Flow During Treadmill Walking on the Gait Pattern in People Post-stroke
NCT03898375 · TERMINATED · logistics pi
“Technical problems”
E-learning+ Rehab Therapy
NCT04245449 · TERMINATED · logistics pi
“Due to COVID-19 and loss of funding”
Maraviroc to Augment Rehabilitation Outcomes After Stroke
NCT03172026 · TERMINATED · slow accrual
“Poor recruitment for each site, partly related to Covid epidemic.”
Reliability of Paired Associative Stimulation-induced Neuroplasticity After Stroke
NCT03861806 · TERMINATED · funding business
“lack of funding”
Evaluation of an Adapted ACT Group for Stroke & Brain Injury Survivors
NCT04995705 · TERMINATED · logistics pi
“Study terminated prematurely due to COVID-19 pandemic. Unable to run face-to-face groups and therefore ACT study was ended before the proposed end date.”
Large Stroke Therapy Evaluation
NCT03811769 · TERMINATED · safety
“Although the planned sample size was 450, enrollment was halted early following an unplanned interim analysis recommended by the Data Safety Monitoring Board because results favoring thrombectomy were reported from other similar trials.”
Tongue Pressure Resistance Training for Swallowing Impairment Post-Stroke
NCT03969095 · TERMINATED · logistics pi
“COVID-19 Pandemic”
Virtual Prism Adaptation Therapy on Hemispatial Neglect
NCT03771872 · TERMINATED · slow accrual
“Recruitment of subjects has been difficult.”
Use of a Tonometer to Identify Epileptogenic Lesions During Pediatric Epilepsy Surgery
NCT04344626 · WITHDRAWN · funding business
“We don't have funding to proceed with this study.”
Transcutaneous Vagus Nerve Stimulation for Motor Recovery After Stroke
NCT03292159 · TERMINATED · funding business
“funding not continued”
Videofluoroscopic Swallowing Study (VFSS)
NCT03387267 · TERMINATED · futility
“Study terminated due to futility”
FAME: Functional Assessment of a Myoelectric Orthosis Hand Orthoses
NCT04266158 · TERMINATED · slow accrual
“Sponsor stoppage of recruitment”
Comparison of Fatigue and Recovery After Stroke Depending on the Usual Management With or Without Physical Training
NCT03259932 · WITHDRAWN · slow accrual
“The study could not be set up due to recruitment and feasibility problems”
Reliability and Validity of Pittsburgh Rehabilitation Participation Scale During Robot Therapy
NCT06756958 · TERMINATED · logistics pi
“The researcher, who recruit, resigned.”
A Study to Evaluate the Safety and Efficacy of Basmisanil in Adults With Severe Motor Impairment Following an Ischemic Stroke
NCT02928393 · TERMINATED · slow accrual
“Low participant enrolment”
Assessment of the WATCHMAN™ Device in Patients Unsuitable for Oral Anticoagulation
NCT02928497 · TERMINATED · regulatory
“The enrollment was prematurely terminated on October 15, 2020, with 481 randomized patients. As discussed in the ASAP-TOO Update Meeting held on 16-September-2020 with FDA (Q150603-S001-A005), termination of enrollment was not due to safety concerns”
PROPEL Randomized Trial
NCT02951338 · TERMINATED · logistics pi
“COVID-19 pandemic”
Clinical, Pharmacological and Molecular Effects of IV and Oral Acetaminophen in Adults With aSAH
NCT02549716 · TERMINATED · funding business
“Funding was stopped”
Feasibility of Home Telehealth Monitoring for Improvement in Management of Hypertension for Secondary Stroke Prevention
NCT03517709 · WITHDRAWN · slow accrual
“No recruitment of subjects”
My Research Legacy Pilot Study
NCT02958098 · TERMINATED · funding business
“Sponsor withdrew funding”
Validation and Standardization of a Battery Evaluation of the Socio-emotional Functions in Various Neurological Pathologies
NCT03052712 · TERMINATED · slow accrual
“not enough patients”
Evaluation of New Diagnostic Methods of Cardio-embolic Related (Atrial Fibrillation) Cerebral Infarction
NCT02948140 · TERMINATED · slow accrual
“Difficulty in recruiting patients”
Usability Testing of a Bilateral Activities of Daily Exercise Robot for Stroke Therapy
NCT02882646 · WITHDRAWN · logistics pi
“Permanently suspended due to equipment issues”
VIT-ARMin Virtual, Intensified and Patient-tailored Robotic Arm Therapy With the Exoskeleton Robot ARMin
NCT02720341 · TERMINATED · logistics pi
“Doctoral students on project defended their thesis.”
Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS)
NCT02313909 · TERMINATED · futility
“Study halted early due to no efficacy improvement over aspirin at an interim analysis and very little chance of showing overall benefit if study were completed”
Changes in Brain Activity Associated With Upper Limb Motor Recovery
NCT02325427 · TERMINATED · funding business
“short of funding support.”
Neuroprotection of Pioglitazone in Acute Ischemic Stroke
NCT02195791 · TERMINATED · slow accrual
“Diffculty in participant enrollment”
Telerobotic Ultrasound for Carotid Imaging - Feasibility Study
NCT05654935 · WITHDRAWN · logistics pi
“Failure to procure funding and technical logistics”
Thrombolysis in Pediatric Stroke (TIPS)
NCT01591096 · TERMINATED · slow accrual
“Lack of patient accrual”
Renal Denervation Hypertension After Stroke
NCT01689415 · TERMINATED · funding business
“Based on results from SYMPLICITY HTN-3”
Use of Dexmedetomidine in Acute Stroke and Cerebral Vasospasm Interventions
NCT01845441 · TERMINATED · logistics pi
“The principal investigator left employment at the sponsoring Institution”
A Prospective Study to Evaluate Use of the Tibion Bionic Leg in Sub-Acute Post-stroke Patients
NCT01558232 · TERMINATED · funding business
“Study was terminated base on Sponsor's decision.”
Video-based Training for Rehabilitation of Upper Limb Functions After Stroke
NCT01242956 · TERMINATED · slow accrual
“Problem to recruit sufficient patient number”
SMARTease Trial: Evaluating Stroke Help Distance Interventions to Improve Cognitive Performance Post-Stroke
NCT01407081 · TERMINATED · slow accrual
“Poor recruitment”
China Stroke Secondary Prevention Trial
NCT01317849 · WITHDRAWN · funding business
“financial assistance financial assistance financial assistance financial assistance financial assistance without financial assistance”
Effects of the Quantity of Repetitive Transcranial Magnetic Stimulation(rTMS) on the Recovery After Stroke
NCT01311271 · TERMINATED · other
“Only two subjects have been recruited from start of the study. We decided to start the study in this topic, after revising the study protocol.”
Assessment of GRASP Medical Device to Improve Arm Coordination After Stroke
NCT01134796 · TERMINATED · slow accrual
“failure to recruit”
Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke (DIAS-4)
NCT00856661 · TERMINATED · other
“The recruitment into DIAS4 has been stopped as the result of DIAS 3 indicates that the study is unlikely to reach its primary endpoint with the current protocol”
Activated Protein C in Acute Stroke Trial
NCT00533546 · TERMINATED · slow accrual
“Lack of recruitment”
Sleep Apnea: Mechanism and Cerebrovascular Consequences
NCT00108602 · WITHDRAWN · funding business
“This study of the overall grant was not pursued as the aims were changed”
Intra-arterial Microplasmin Administration in Patients With Acute Intracranial Vertebrobasilar Artery Occlusion
NCT00123266 · TERMINATED · funding business
“Sponsor's decision not to pursue development of uPLi for vascular conditions.”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.