Autopsy report · NCT00452114

In-exsufflator Cough Assist Device in Patients With Symptomatic Bronchiectasis

“interim analysis indicates statistical futility for primary outcomes”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 years 11 months after it had already started.
• Ran for about 4 years 1 month before it stopped.
• 28 participants enrolled.
• Results were posted on the registry 4 years 10 months after it ended.

Vital statistics

Status

Terminated

Phase

Na

Sponsor

University of Massachusetts, Worcester

Sponsor type

University, hospital or other

Conditions

Bronchiectasis

Interventions

In-Exsufflator Cough Assist Device; Active Comparator: Flutter Valve Device

Participants

28

Sites

2

Countries

United States

Trials that died the same way

• Sevoflurane and Percutaneous Coronary Intervention by Stent
  “interim analysis suggests futility” (76% match in meaning)
• Bivalirudin Infusion for Ventricular Infarction Limitation
  “Futility at the interim analysis.” (75% match in meaning)
• Study of M5049 in DM and PM Participants (NEPTUNIA)
  “Based on interim analyses for futility” (74% match in meaning)
• Microdosed Atropine 0.1% and 0.01% Ophthalmic Solutions for Reduction of Pediatric Myopia Progression
  “Interim Analysis reviewed by Data Monitoring Committee indicated futility” (74% match in meaning)
• Efficacy and Safety Study of DP-b99 in Treating Acute Ischemic Stroke
  “The result of a pre-planned interim futility analysis” (73% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.