Autopsy report · NCT00479466

Dose-Range Finding Study for MK0893 (0893-008)

“Sufficient data regarding the dose-response to MK-0893 had been obtained from the first cohort of the study to assess the safety and efficacy”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 months before it started.
• Ran for about 10 months before it stopped.
• 342 participants enrolled.
• Results were posted on the registry 3 years 6 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Merck Sharp & Dohme LLC

Sponsor type

Industry

Conditions

Diabetes Mellitus, Type 2

Interventions

MK0893; Metformin; Placebo to MK0893; Placebo to Metformin

Participants

342

Trials that died the same way

• Study to Evaluate the Safety of AT2220 (Duvoglustat) in Pompe Disease
  “Per protocol, 3 sequential dose cohorts were planned. Study discontinued by Sponsor based upon serious adverse events in first 2 of 3 participants in Cohort 1.” (62% match in meaning)
• Study of NGX-4010 for Treatment of Painful HIV-Associated Neuropathy
  “Terminated in view of the C107 findings demonstrating efficacy at doses of 90 and 30 minutes” (60% match in meaning)
• A Study With BPS-314d-MR-PAH-303 in Participants With Pulmonary Arterial Hypertension
  “The pivotal study, BPS-314d-MR-PAH-302 (NCT01908699), failed to demonstrate efficacy.” (59% match in meaning)
• Safety and Efficacy Evaluation of Bosutinib Plus Atezolizumab in Newly Diagnosed Chronic Leukemia Adult Patients
  “The study has been prematurely terminated due to the onset of 2 dose limiting toxicities in 2 patients.” (59% match in meaning)
• A Phase I Trial Evaluating mFOLFOX6 and Avastin With Nexavar as First-Line Treatment for Metastatic Colorectal Cancer
  “Dose limiting toxicity at the lowest planned dose level.” (59% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.