Autopsy report · NCT00359424

Interventional Management of Stroke (IMS) III Trial

“NINDS/NIH-DSMB recommended halting trial due to futility, no safety concerns.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 6 years 8 months before it stopped.
• 656 participants enrolled.
• Results were posted on the registry 8 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Joseph Broderick

Sponsor type

University, hospital or other

Conditions

Stroke

Interventions

IV rt-PA alone; endovascular therapy

Participants

656

Sites

71

Countries

Australia, Canada, France, Germany, Netherlands, Spain, Switzerland, United States

Trials that died the same way

• Study to Investigate the Safety and Efficacy of Lithium in Volunteers With Amyotrophic Lateral Sclerosis (ALS)
  “NINDS DSMB recommended trial be terminated for futility after reviewing an interim analysis of 84 subjects.” (76% match in meaning)
• AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke
  “The DSMB halted the trial prematurely due to futility without any safety concerns.” (70% match in meaning)
• ATG Plus Low-dose PT-Cy for GVHD Prevention
  “DSMB recommended halting the study owing to futility after the first interim analysis in August 2024.” (60% match in meaning)
• Pilot Study of Varenicline (Chantix®) in the Treatment of Friedreich's Ataxia
  “The DSMB recommended that the study be stopped as a result of concerns regarding safety and intolerability and insufficient evidence of efficacy.” (60% match in meaning)
• Helping HIV Infected Patients in South Africa Adhere to Drug Regimens
  “DSMB stopped trial for futility” (59% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.