Autopsy report · NCT00144924

Open vs Laparoscopic Pyloromyotomy for Pyloric Stenosis

“The aim was to recruit 200 infants (100 per group); however, the data monitoring and ethics committee recommended halting the trial before full recruitment because of significant treatment benefit in one group at interim analysis.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 year 3 months after it had already started.
• Ran for about 2 years 11 months before it stopped.
• 180 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Na

Sponsor

Institute of Child Health

Sponsor type

University, hospital or other

Conditions

Pyloric Stenosis

Interventions

laparoscopy pyloromyotomy; open pyloromytomy

Participants

180

Sites

1

Countries

United Kingdom

Trials that died the same way

• Comparing Satisfaction With a Participatory Driven Web-application and a Standard Website
  “The primary trial was stopped. Since, a feasibility study showed that recruitment was not feasible. We obtain a recruitment rate of 15 %.” (66% match in meaning)
• Study of Intraparenchymal Therapy as Adjunct Therapy in Patients With Recurrent, Resectable Glioblastoma Multiforme.
  “The decision to terminate the trial was based on the slow rate of recruitment across the programme of studies” (65% match in meaning)
• Efficacy Study of Topical Twice Weekly Fluticasone Treatment to Reduce Relapse in Atopic Dermatitis in Children
  “Patient recruitment is very slow, economic grant has ended and the number of patients is enough according to sample size (22 children/ arm).” (62% match in meaning)
• Effect of Citalopram on Chest Pain in Patients With Functional Chest Pain
  “The clinical trial has ended prematurely due to low patient recruitment” (62% match in meaning)
• Ovarian Cancer Treatment With a Liposome Formulated mRNA Vaccine in Combination With (Neo-)Adjuvant Chemotherapy
  “Despite the extension of the original recruitment period, the target number of evaluable patients defined in the study protocol could not be reached and recruitment for the trial was stopped at that point of time.” (62% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.