Autopsy report · NCT04163094

Ovarian Cancer Treatment With a Liposome Formulated mRNA Vaccine in Combination With (Neo-)Adjuvant Chemotherapy

“Despite the extension of the original recruitment period, the target number of evaluable patients defined in the study protocol could not be reached and recruitment for the trial was stopped at that point of time.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 3 years 7 months before it stopped.
• 8 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

University Medical Center Groningen

Sponsor type

University, hospital or other

Conditions

Ovarian Cancer

Interventions

W_ova1 Vaccine

Participants

8

Sites

1

Countries

Netherlands

Trials that died the same way

• All-On-4® Treatment Concept
  “The study stopped as the performance of the study showed insufficient patient recruitment.” (76% match in meaning)
• Pleural Suction Additional to Thoracostomy Tube for Traumatic Hemothorax
  “It was not possible to achieve adequate recruitment to complete the necessary sample. The rate at which patients are recruited does not allow for continued participation” (75% match in meaning)
• Omission of Surgery in Clinically Low-risk HER2positive Breast Cancer With High HER2 Addiction and a Complete Response Following Standard Anti-HER2-based Neoadjuvant Therapy
  “The study was prematurely halted primarily due to low patient accrual. Despite efforts to optimize recruitment, the enrollment rate remained insufficient to meet the predefined targets, and continuation was deemed unfeasible” (74% match in meaning)
• Efficacy of Rituximab in Acute Cellular Rejection in Renal Transplant Patients
  “The planned recruitment number of 180 Patient could not been achieved.” (74% match in meaning)
• Endoscopic Full Thickness Resection of Gastric Subepithelial Tumors (FROST)
  “According to study protocol the trial was terminated because the recruitment of trial participants was insufficient.” (72% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.