Autopsy report · NCT05470400

A Clinical Trial to Evaluate Safety, Tolerability, and Immunogenicity of Adjuvanted HIV-1 Fusion Peptide Conjugate Vaccine Alone or in Prime-Boost Regimens With Adjuvanted HIV-1 Envelope Trimer 4571 and HIV-1 Trimer 6931 Vaccines in Healthy Adults

“The HVTN 303 IND was placed on clinical hold, and recruitment did not resume.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 months before it started.
• Ran for about 1 year 5 months before it stopped.
• 44 participants enrolled.
• Results were posted on the registry 1 year 2 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

National Institute of Allergy and Infectious Diseases (NIAID)

Sponsor type

US National Institutes of Health

Conditions

HIV

Interventions

FP conjugate vaccine (25 mcg); FP conjugate vaccine (200 mcg); Trimer 6931 (100 mcg); Trimer 6931 (200 mcg); Trimer 4571 (200 mcg); Trimer 4571 (100 mcg)

Participants

44

Sites

6

Countries

United States

Trials that died the same way

• Comprehensive Optimization At-time of Radical Cystectomy Intervention
  “Recruitment efforts had begun; however, no participants were enrolled, and the trial had been on a prolonged hold.” (61% match in meaning)
• Utilizing a Promotora Model for Rural Adult Hispanics Diagnosed With Metabolic Syndrome: A Clinical Trial
  “Funding for the study was not received. No recruitment ever occurred.” (59% match in meaning)
• Does Inhaled Busedonide or Fluticasone Impair Adrenal Function?
  “recruiting subjects did not start.” (59% match in meaning)
• Surgery Induced Trauma After Total Versus Medial Unicompartmental Knee Arthroplasty (SITA)
  “The study was terminated due to poor participant accrual. Recruitment was limited by competing clinical studies at the participating site, and the resources required to prolong the recruitment period were not available.” (59% match in meaning)
• To Determine the Objective Response Rate of 4 Cycles of Docetaxel + Anthracycline (Epirubicin or Doxorubicine) Followed by 4 Cycles of Docetaxel Single Agent
  “the study was early terminated due to lack of recruitment.” (58% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.