National Institute of Allergy and Infectious Diseases (NIAID)

Why trials sponsored by National Institute of Allergy and Infectious Diseases (NIAID) stopped, in this sample of ClinicalTrials.gov.

24 stopped trials with a clear reason; 88% ended for non-scientific reasons.

Trials

• Safety Evaluation of PfSPZ Vaccine in Pregnant Women in Mali (MalVIP1)
  NCT05652504 · WITHDRAWN · funding business
  “Sponsor discontinued development of the investigational vaccine for this protocol and shifted to an alternative investigational product.”
• Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV
  NCT06705478 · SUSPENDED · slow accrual
  “Temporarily Closed (Paused) to Accrual”
• A Clinical Trial to Evaluate the Safety and Immunogenicity of Glycan-trimmed HIV-1 Nanoparticle Vaccine (UVAX-1107), Followed by Homologous or Wild-type HIV-1 Nanoparticle Vaccine (UVAX-1197) Boost, Each Adjuvanted With 3M-052-AF + Alum in Adult Participants Without HIV
  NCT06905275 · SUSPENDED · slow accrual
  “Temporarily Closed (Paused) to Accrual”
• Skin Immunity Sample Collection Involving Blisters and Biopsies
  NCT03921515 · WITHDRAWN · slow accrual
  “Study closed by PI, no enrollment.”
• Transcutaneous Cervical Vagus Nerve Stimulation (tcVNS) in JIA
  NCT05710640 · TERMINATED · funding business
  “Study was terminated due to feasibility concerns and budget constraints.”
• A Clinical Trial to Evaluate Safety, Tolerability, and Immunogenicity of Adjuvanted HIV-1 Fusion Peptide Conjugate Vaccine Alone or in Prime-Boost Regimens With Adjuvanted HIV-1 Envelope Trimer 4571 and HIV-1 Trimer 6931 Vaccines in Healthy Adults
  NCT05470400 · TERMINATED · regulatory
  “The HVTN 303 IND was placed on clinical hold, and recruitment did not resume.”
• A Study to Evaluate the Anti-inflammatory Effects of Letermovir (Prevymis) in Adults With Human Immunodeficiency Virus (HIV)-1 and Asymptomatic Cytomegalovirus (CMV) Who Are on Suppressive Antiretroviral Therapy, Plus Its Effect on Chronic Inflammation, HIV Persistence and Other Clinical Outcomes.
  NCT04840199 · TERMINATED · slow accrual
  “Permanently closed to screening and accrual due to futility”
• Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum
  NCT04518228 · TERMINATED · slow accrual
  “The study was closed to accrual early based on Study Monitoring Committee review indicating that the study objectives had either been achieved or could not be met within a reasonable timeframe for the then-open arms.”
• Liver Transplantation With Tregs at UCSF
  NCT03654040 · TERMINATED · funding business
  “The study was terminated by the Sponsor prior to any participants receiving the investigational product.”
• Efficacy and Microfilaricidal Kinetics of Imatinib for the Treatment of Loa Loa
  NCT02644525 · TERMINATED · futility
  “Planned interim analysis demonstrated futility of intervention”
• A Double-Blind Placebo-Control Dose Escalating Study to Evaluate the Safety and Immunogenicity of dmLT by Oral, Sublingual and Intradermal Vaccination in Adults Residing in an Endemic Area
  NCT03548064 · TERMINATED · logistics pi
  “COVID 19 cases at the site”
• Evaluating the Safety and Immunogenicity of the IHV01 Protein Vaccine Primed and Co-Administered With HIV DNA CON-S Env Vaccine in Healthy, HIV-1-Uninfected Adults
  NCT03505060 · WITHDRAWN · manufacturing supply
  “One of the study products is no longer available for clinical trial use.”
• Safety and Efficacy Study of Oral Fosfomycin Versus Oral Levofloxacin to Treat Complicated Urinary Syndromes (FOCUS)
  NCT03697993 · TERMINATED · slow accrual
  “inadequate enrollment.”
• A Single Dose of Pembrolizumab in HIV-Infected People
  NCT03367754 · TERMINATED · slow accrual
  “Difficulty with subject recruitment”
• Evaluating the Infectivity, Safety and Immunogenicity of a Recombinant Live-Attenuated Respiratory Syncytial Virus Vaccine (RSV LID cp ΔM2-2) in RSV-Seronegative Infants 6 to 24 Months of Age
  NCT02890381 · TERMINATED · futility
  “Interim data indicated this vaccine will not meet the protocol criteria for a good vaccine candidate.”
• BMT and High Dose Post-Transplant Cyclophosphamide for Chimerism Induction and Renal Allograft Tolerance
  NCT02029638 · TERMINATED · slow accrual
  “Slow accrual”
• Randomized MMF Withdrawal in Systemic Lupus Erythematosus (SLE)
  NCT01946880 · TERMINATED · slow accrual
  “Slow enrollment.”
• Safety and Efficacy of Desensitization Therapy in Sensitized Participants Awaiting Heart Transplantation
  NCT01769443 · TERMINATED · slow accrual
  “Inability to enroll within funding period”
• Inducing Remission in Type 1 Diabetes With Alefacept
  NCT00965458 · TERMINATED · funding business
  “Manufacturer discontinued production of Amevive®: business decision.”
• A Randomized Double-Blind Control-Comparison Crossover Trial of Oral Glutamine to Suppress Frequently Recurrent Herpes Labialis
  NCT00913692 · TERMINATED · slow accrual
  “Terminated due to slow recruitment.”
• Effect of Ranitidine on Hyper-IgE Recurrent Infection (Job's) Syndrome
  NCT00527878 · TERMINATED · slow accrual
  “Failure to enroll adequate patient numbers due to small number of eligible patients”
• Stem Cell Transplantation After Reduced-Dose Chemotherapy for Patients With Sickle Cell Disease or Thalassemia
  NCT00034528 · TERMINATED · slow accrual
  “Due to slow recruitment”
• Steroid Withdrawal in Pediatric Kidney Transplant Recipients
  NCT00023244 · TERMINATED · safety
  “Effective August 13, 2004: Unanticipated high incidence of post-transplant lymphoproliferative disorder”
• SCH708980 With and Without AmBisome for Visceral Leishmaniasis
  NCT01437020 · WITHDRAWN · manufacturing supply
  “Drug Product no longer available.”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.