Autopsy report · NCT05219578

RTX-224 Monotherapy in Patients With Solid Tumors

“The Sponsor terminated study after dosing 2 dose groups (7 pts) and closed trial on 11/30/22. RTX-224 was well-tolerated with no DLTs, no related deaths, SAEs or Gr. 3/4 AEs and cleared rapidly (w/in 10 min).”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 11 months before it stopped.
• 7 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 1, Phase 2

Sponsor

Rubius Therapeutics

Sponsor type

Industry

Conditions

Non Small Cell Lung Cancer; Cutaneous Melanoma; Head and Neck Squamous Cell Carcinoma; Urothelial Carcinoma; TNBC - Triple-Negative Breast Cancer

Interventions

RTX-224

Participants

7

Sites

5

Countries

United States

Trials that died the same way

• A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)
  “The Sponsor terminated the study due to early dose-limiting toxicities.” (69% match in meaning)
• Safety Study of rhASM Enzyme Replacement Therapy in Adults With Acid Sphingomyelinase Deficiency (Niemann-Pick Disease)
  “Terminated by sponsor - Single dose safety objective achieved.” (63% match in meaning)
• A Study Of Safety, Tolerability And Effectiveness Of Recifercept In Children With Achondroplasia
  “The study was terminated due to lack of efficacy at any of the tested doses on 18th November 2022. The decision to terminate the study is not related to a safety concern.” (62% match in meaning)
• Common Safety Follow-up Trial of Tecemotide (L-BLP25)
  “The study is terminated prematurely as the sponsor decided to discontinue program with Tecemotide in NSCLC.” (62% match in meaning)
• Nab-Sirolimus and Pazopanib Hydrochloride in Treating Patients With Advanced Nonadipocytic Soft Tissue Sarcomas
  “Study was terminated at completion of the Phase 1 dose escalation due to loss of financial support.” (62% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.