Autopsy report · NCT03660930

Nab-Sirolimus and Pazopanib Hydrochloride in Treating Patients With Advanced Nonadipocytic Soft Tissue Sarcomas

“Study was terminated at completion of the Phase 1 dose escalation due to loss of financial support.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 7 months before it started.
• Ran for about 5 years 4 months before it stopped.
• 19 participants enrolled.
• Results were posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 1, Phase 2

Sponsor

University of Washington

Sponsor type

University, hospital or other

Conditions

Advanced Soft Tissue Sarcoma; Locally Advanced Soft Tissue Sarcoma; Metastatic Soft Tissue Sarcoma

Interventions

Sirolimus Albumin-bound Nanoparticles; Pazopanib hydrochloride

Participants

19

Sites

1

Countries

United States

Trials that died the same way

• Evaluation of Revumenib in Participants With Colorectal Cancer and Other Solid Tumors
  “Study was terminated by sponsor after Phase 1b as pre-defined signals of efficacy were not met in the Phase 1b dose expansion cohort.” (73% match in meaning)
• A Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease
  “Study stopped due to business reasons, following full enrollment of the first dose cohort.” (71% match in meaning)
• A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)
  “The Sponsor terminated the study due to early dose-limiting toxicities.” (70% match in meaning)
• Alvimopan Use in Polytraumatized Patients
  “This study was terminated due to failure to enroll, a low volume of patients met criteria.” (70% match in meaning)
• Therapeutic Exercise in Patients With Hemophilia
  “The Study was terminated due to lack of funding for continuing” (70% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.