Autopsy report · NCT05125068

Safety and Efficacy of AT-1501 in Patients With IgA Nephropathy (IgAN)

“An administrative decision was made to terminate the AT-1501-N205 study. This voluntary business-related decision was not related to the safety of tegoprubart (AT-1501). Available safety data demonstrated tegoprubart to be safe and well tolerated.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 4 months before it started.
• Ran for about 1 year 4 months before it stopped.
• 24 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Eledon Pharmaceuticals

Sponsor type

Industry

Conditions

IgA Nephropathy; IgAN

Interventions

AT-1501

Participants

24

Sites

26

Countries

Australia, Croatia, Malaysia, New Zealand, Philippines, Poland, Spain, Sri Lanka, Thailand, United Kingdom

Trials that died the same way

• A Dose Escalation Study to Assess the Safety and Tolerability of HMPL-453 in Patients With Advanced Solid Malignancies
  “The study was terminated on 23AUG2018 for safety reasons.” (60% match in meaning)
• Safety and Efficacy of Tegaserod in Opioid-induced Constipation in Patients With Non-cancer Pain.
  “This study was terminated early as a result of regulatory action suspending tegaserod use in 2007” (59% match in meaning)
• Extension Study of ACE-031 in Subjects With Duchenne Muscular Dystrophy
  “This study was terminated based on preliminary safety data.” (58% match in meaning)
• Efficacy and Safety of Clevudine Compared With Adefovir in Patients With HBeAg Positive Chronic Hepatitis Due to Hepatitis B Virus
  “The study was terminated in the interest of patient safety.” (57% match in meaning)
• A Study Of Safety, Tolerability And Effectiveness Of Recifercept In Children With Achondroplasia
  “The study was terminated due to lack of efficacy at any of the tested doses on 18th November 2022. The decision to terminate the study is not related to a safety concern.” (57% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.