Autopsy report · NCT00414024

Safety and Efficacy of Tegaserod in Opioid-induced Constipation in Patients With Non-cancer Pain.

“This study was terminated early as a result of regulatory action suspending tegaserod use in 2007”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 months before it started.
• Ran for about 3 months before it stopped.
• 11 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Novartis

Sponsor type

Industry

Conditions

Opioid-induced Constipation

Interventions

Tegaserod

Participants

11

Sites

6

Countries

China, Egypt, Singapore, Taiwan, United States, Venezuela

Trials that died the same way

• Safety and Efficacy of AT-1501 in Patients With IgA Nephropathy (IgAN)
  “An administrative decision was made to terminate the AT-1501-N205 study. This voluntary business-related decision was not related to the safety of tegoprubart (AT-1501). Available safety data demonstrated tegoprubart to be safe and well tolerated.” (59% match in meaning)
• Common Safety Follow-up Trial of Tecemotide (L-BLP25)
  “The study is terminated prematurely as the sponsor decided to discontinue program with Tecemotide in NSCLC.” (59% match in meaning)
• Relative Bioavailability Study of Ropinirole Implants in Parkinson's Patients on L-Dopa Switched From Oral Ropinirole
  “This study was terminated for reasons not related to efficacy or safety” (56% match in meaning)
• A Study of TCD601 (Siplizumab) in New Onset Type 1 Diabetes Patients
  “The study has been early terminated due to business reasons. This decision is not related to any safety, efficacy, or regulatory concerns.” (56% match in meaning)
• A Dose Exploration Study With Birabresib (MK-8628) in Participants With Selected Hematologic Malignancies (MK-8628-005)
  “This study was terminated due to limited efficacy and not due to safety reasons” (55% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.