Autopsy report · NCT05006573

Efficacy and Safety of Benralizumab in Patients With Non-cystic Fibrosis Bronchiectasis

“Due to the decision to stop recruitment early, enrolment into the MAHALE trial was terminated in August 2022; 139 patients were screened and 100 randomised to IP.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 2 years 9 months before it stopped.
• 100 participants enrolled.
• Results were posted on the registry 1 year 3 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

AstraZeneca

Sponsor type

Industry

Conditions

Non-cystic Fibrosis Bronchiectasis

Interventions

Benralizumab; Placebo to Benralizumab

Participants

100

Sites

48

Countries

Argentina, Australia, Canada, China, Denmark, Germany, India, Italy, Philippines, Poland, Russia, South Korea and more

Trials that died the same way

• Stop Exogenous Allergic Alveolitis (EAA) in Childhood
  “After several years of recruitment only 4 patients were included. Study timelines for study completition too long. Decided to terminate trial.” (70% match in meaning)
• A Trial in Painful Diabetic Peripheral Neuropathy With GRT3983Y
  “Trial was stopped due to difficult enrolment” (67% match in meaning)
• Study of Intraparenchymal Therapy as Adjunct Therapy in Patients With Recurrent, Resectable Glioblastoma Multiforme.
  “The decision to terminate the trial was based on the slow rate of recruitment across the programme of studies” (65% match in meaning)
• Endoscopic Full Thickness Resection of Gastric Subepithelial Tumors (FROST)
  “According to study protocol the trial was terminated because the recruitment of trial participants was insufficient.” (64% match in meaning)
• Neoadjuvant Lu-PSMA Radioligand Therapy and Ipilimumab in Men With Very High-risk Prostate Cancer
  “The clinical trial has been terminated due to the revocation of funding. Although one subject was enrolled, the participant withdrew prior to receiving any treatment. No trial-related procedures generating evaluable clinical data were performed.” (64% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.