Autopsy report · NCT05000216

COVID-19 Booster Vaccine in Autoimmune Disease Non-Responders

“The study was closed due to continued enrollment hurdles.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 2 years 7 months before it stopped.
• 258 participants enrolled.
• Results were posted on the registry 1 year 5 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

National Institute of Allergy and Infectious Diseases (NIAID)

Sponsor type

US National Institutes of Health

Conditions

Rheumatoid Arthritis (RA); Systemic Lupus Erythematosus (SLE); Pemphigus Vulgaris; Multiple Sclerosis (MS); Systemic Sclerosis (SSc); Pediatric SLE

Interventions

Moderna mRNA-1273; BNT162b2; Ad26.COV2.S; Continue IS (MMF or MPA); Continue IS (MTX); Continue IS (B cell depletion therapy)

Participants

258

Sites

29

Countries

United States

Trials that died the same way

• Intensity Modulated Radiation Therapy (IMRT) for Patients With Rectal Cancer
  “The study was closed to enrollment due to slow accrual.” (86% match in meaning)
• Ruxolitinib for Early Lung Dysfunction After Hematopoietic Stem Cell Transplant
  “Study closed due to slow enrollment.” (84% match in meaning)
• Study Of CP-751,871 In Combination With Exemestane In Postmenopausal Women With Hormone Receptor Positive Advanced Breast Cancer
  “This study was closed to enrollment as of 13 May 2011 due to business reasons. Premature closure was not prompted by any safety or efficacy concerns.” (84% match in meaning)
• Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders
  “Study closed before total enrollment met.” (82% match in meaning)
• Dexamethasone to Treat Acute Chest Syndrome in People With Sickle Cell Disease
  “Study was closed June 23, 2008 due to low enrollment.” (82% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.