Autopsy report · NCT04549025

Study of PD-1 Inhibitor JTX-4014 Alone and in Combination With Vopratelimab in Biomarker-selected Subjects With Metastatic NSCLC After One Prior Platinum-containing Regimen

“The Sponsor decided to discontinue development of pimivalimab prior to the planned study completion. At the time of the decision to discontinue development, enrollment in the study had been completed.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 months before it started.
• Ran for about 3 years 6 months before it stopped.
• 69 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Jounce Therapeutics, Inc.

Sponsor type

Industry

Conditions

NSCLC

Interventions

Pimivalimab; Vopratelimab

Participants

69

Sites

72

Countries

Belarus, Bosnia and Herzegovina, Bulgaria, Croatia, Georgia, Hungary, Latvia, Moldova, Romania, Russia, Serbia, Slovakia and more

Trials that died the same way

• Study of Satraplatin (JM-216) in Combination With Docetaxel
  “Sponsor decided to discontinue study drug development.” (66% match in meaning)
• HIV-1 Vaccine Test in Uninfected Adult Volunteers
  “The study product was revised. PI withdrew the study without enrolling participants..” (65% match in meaning)
• Consolidation Therapy in Patients With Metastatic Solid Malignancies
  “Sponsor decision to discontinue study.” (64% match in meaning)
• A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Low Back Pain
  “Based on lack of efficacy in PAI2003, sponsor made the decision to discontinue the trial.” (63% match in meaning)
• Study of Magrolimab Combinations in Patients With Relapsed/Refractory Multiple Myeloma
  “This study was terminated early due to the Sponsor's decision to discontinue development of the investigational drug and close the program.” (62% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.