Autopsy report · NCT04469725

KN046 (a Humanized PD-L1/CTLA4 Bispecific Single Domain Fc Fusion Protein Antibody) in Subjects With Thymic Carcinoma

“The termination of this study does not involve safety issues. The overall safety of KN046 is good, and no new safety signals have been found. The decision to terminate this study was made due to the adjustment of the sponsor's development strategy.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 5 months before it started.
• Ran for about 2 years 7 months before it stopped.
• 95 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Jiangsu Alphamab Biopharmaceuticals Co., Ltd

Sponsor type

Industry

Conditions

Thymic Carcinoma

Interventions

KN046

Participants

95

Sites

1

Countries

China

Trials that died the same way

• Study of the Influence of Liver Function on Blood Concentrations of Runcaciguat in Participants With Different Degrees of Liver Impairment
  “This study is prematurely terminated due to changes in sponsor's overall development strategy. The decision of termination is not related to any safety concern of the compound.” (64% match in meaning)
• Ponatinib in Newly Diagnosed Chronic Myeloid Leukemia (CML) (EPIC)
  “Study terminated based on evaluation of safety data.” (64% match in meaning)
• Ivosidenib, Nivolumab, and Ipilimumab Combination in Previously Treated Subjects With Nonresectable or Metastatic IDH1 Mutant Cholangiocarcinoma
  “The sponsor decided to terminate the study during the safety lead-in phase.” (64% match in meaning)
• Extension Study of ACE-031 in Subjects With Duchenne Muscular Dystrophy
  “This study was terminated based on preliminary safety data.” (62% match in meaning)
• A Study to Assess the Safety, Tolerability and Effectiveness of MT-0814 for the Treatment of Age-related Macular Degeneration
  “The study terminated for safety reasons” (62% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.