Autopsy report · NCT04329923

The PATCH Trial (Prevention And Treatment of COVID-19 With Hydroxychloroquine)

“Cohort 1: slow accrual Cohort 2: Other studies showed no benefit Cohort 3: Study met pre-specificied futility analysis at planned second interim analysis”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 7 months before it stopped.
• 173 participants enrolled.
• Results were posted on the registry 1 month after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Ravi Amaravadi, MD

Sponsor type

University, hospital or other

Conditions

COVID-19

Interventions

Hydroxychloroquine Sulfate 400 mg twice a day; Hydroxychloroquine Sulfate 600 mg twice a day; Hydroxychloroquine Sulfate 600 mg once a day; Placebo oral tablet

Participants

173

Sites

1

Countries

United States

Trials that died the same way

• Efficacy and Safety Study of DP-b99 in Treating Acute Ischemic Stroke
  “The result of a pre-planned interim futility analysis” (71% match in meaning)
• Tissue Adhesive vs. Sterile Strips After Cesarean Delivery
  “Based on results of an interim analysis, the study was halted for futility” (69% match in meaning)
• Study of M5049 in DM and PM Participants (NEPTUNIA)
  “Based on interim analyses for futility” (69% match in meaning)
• A Study of Idasanutlin With Cytarabine Versus Cytarabine Plus Placebo in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)
  “The study was stopped for futility based on efficacy results at the interim analysis; no unexpected safety findings were observed.” (69% match in meaning)
• CONvalescent Plasma for Hospitalized Adults With COVID-19 Respiratory Illness (CONCOR-1)
  “Study was terminated after the planned interim analysis as the pre-defined futility threshold was met” (69% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.