Autopsy report · NCT04273269

A Safety and Efficacy Study of LYS-GM101 Gene Therapy in Patients With GM1 Gangliosidosis

“The clinical trial is closed due to Lysogene's cessation of activities. This study closure is not due to safety reasons.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 year 4 months before it started.
• Ran for about 2 years before it stopped.
• 5 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 1, Phase 2

Sponsor

LYSOGENE

Sponsor type

Industry

Conditions

GM1 Gangliosidosis

Interventions

LYS-GM101

Participants

5

Sites

3

Countries

France, United Kingdom, United States

Trials that died the same way

• A Study of [14C]-LY3023703 in Healthy Participants
  “Due to safety results from another trial of LY3023703. No participants in this study received study drug.” (66% match in meaning)
• Subcutaneous Recombinant Human Hyaluronidase: Workflow Analysis and Emergency Department Design
  “This study was closed before accrual due to FDA recall of Medication” (64% match in meaning)
• Carboplatin/Cisplatin + Etoposide + Benmelstobart Sequential Benmelstobart Combined With Anlotinib Versus Carboplatin/Cisplatin + Etoposide + Tislelizumab Sequential Tislelizumab in the Treatment of Extensive Stage Small Cell Lung Cancer
  “This study was closed due to business reasons. Closure was not prompted by any safety or efficacy concerns.” (63% match in meaning)
• Combination Chemotherapy and Inotuzumab Ozogamicin in Treating Patients With B Acute Lymphoblastic Leukemia
  “the study was closed early due to competing trials” (63% match in meaning)
• Exploratory Study of Farletuzumab to Treat Resectable, Non-functioning Pituitary Adenomas
  “Trial terminated due to focus of primary therapeutic areas.” (62% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.