Autopsy report · NCT04157036

Evaluation of Methylprednisolone or Ibuprofen on Efficacy of Nerve Blocks With Symptomatic Irreversible Pulpitis

“COVID halted recruitment for 2 years. A majority of patients eligible for the study had already taken preoperative analgesics, which disqualified them for the study.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 3 months before it started.
• Ran for about 1 year 8 months before it stopped.
• 3 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Walter Reed National Military Medical Center

Sponsor type

US federal agency

Conditions

Irreversible Pulpitis

Interventions

Ibuprofen; Methylprednisolone

Participants

3

Sites

1

Countries

United States

Trials that died the same way

• Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study)
  “The study was stopped due to slower than expected recruitment and the additional limitations on clinical research imposed by the COVID-19 pandemic, both of which made study completion within a reasonable timeframe appear unlikely.” (75% match in meaning)
• New Formulations of Propafenone to Treat Atrial Fibrillation
  “Study halted/terminated prematurely due to COVID.” (73% match in meaning)
• Impact of T Cells on Age-related Vascular Dysfunction: A Translational Approach
  “COVID initially delayed plans to begin recruitment of subjects. Subsequently, the departure of a clinical investigator and loss of access to equipment and study subject population resulted in study termination before any subjects were enrolled.” (72% match in meaning)
• Comparison of Efficacy of Behavioral Approaches for Treatment of Insomnia
  “Study halted prematurely and will not resume; participants are no longer being examined or receiving intervention. COVID Complications.” (70% match in meaning)
• Zambia Common Elements Treatment Approach Pilot Study
  “COVID-19 precluded the study team from being able to complete all follow-up assessments.The study was halted on March 17, 2020 and did not resume.” (69% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.