Autopsy report · NCT04037891

Topical rVA576 for Treatment of Atopic Keratoconjunctivitis

“The trial has terminated early due to the disruptions caused by the ongoing COVID-19 pandemic. The decision was not related to any efficacy, safety or clinical concerns regarding rVA576.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 1 year 2 months before it stopped.
• 12 participants enrolled.
• Results were posted on the registry 4 years 10 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 1, Phase 2

Sponsor

AKARI Therapeutics

Sponsor type

Industry

Conditions

Keratoconjunctivitis, Atopic; Keratoconjunctivitis, Vernal; Conjunctivitis, Allergic

Interventions

rVA576; Placebo; rVA576

Participants

12

Sites

9

Countries

Spain, United Kingdom

Trials that died the same way

• PERSEUS-PS Randomized Controlled Trial
  “The trial prematurely terminated as a result of the COVID-19 pandemic.” (74% match in meaning)
• A Study to Assess the Therapeutic Effect and Safety of Adjunctive AKST4290 in Subjects With Bullous Pemphigoid
  “The study was prematurely terminated by the Sponsor due to operational challenges stemming from the coronavirus disease 2019 (COVID-19) pandemic, treatment limitations, rarity of the disease, and drug supply considerations.” (70% match in meaning)
• Study to Evaluate the Efficacy and Safety of FX006 in Patients With Glenohumeral Osteoarthritis or Shoulder Adhesive Capsulitis
  “The study was terminated prematurely due to the COVID-19 pandemic creating uncertainty impacting trial progress and costs.” (69% match in meaning)
• A Phase I Clinical Study for Evaluating the Safety and Efficacy of MASCT-I in Patients With Advanced Solid Tumors
  “The study was terminated early due to the COVID-19 pandemic and sponsor's funding constraints, based on promising preliminary safety and efficacy data.” (68% match in meaning)
• Acceptability, Feasibility and Safety of a Yoga Program for Chronic Pain in Sickle Cell Disease
  “Study terminated due to COVID-19 pandemic.” (65% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.