Autopsy report · NCT03838367

Leronlimab (PRO 140) Combined With Carboplatin in Patients With Cytokine Chemokine Receptor 5 Positive (CCR5+) mTNBC

“Study terminated prematurely due to business reasons. Participants are no longer examined or receiving intervention.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 3 months before it started.
• Ran for about 3 years 5 months before it stopped.
• 10 participants enrolled.
• Results were posted on the registry 3 years after it ended.

Vital statistics

Status

Terminated

Phase

Phase 1, Phase 2

Sponsor

CytoDyn, Inc.

Sponsor type

Industry

Conditions

Triple Negative Breast Neoplasms

Interventions

350 mg leronlimab; 525 mg leronlimab; 700 mg leronlimab; AUC 5 Carboplatin; Maximum Tolerated Dose (MTD) of leronlimab

Participants

10

Sites

2

Countries

United States

Trials that died the same way

• Starting the Conversation
  “The study was terminated due to a small number of study participants.” (85% match in meaning)
• An Evaluation Of The Effectiveness And Safety Of Anidulafungin Compared To Caspofungin For The Treatment Of Deep Tissue Infection Due To Candida
  “The study was terminated prematurely on May 18, 2012 due to slow enrollment. The study was not terminated due to any safety issues or concerns.” (83% match in meaning)
• Function, Pain, and Alignment Following Knee Replacement for the Treatment of Osteoarthritis
  “The study was prematurely terminated due to a long pause in study activities and significant missing participant data.” (83% match in meaning)
• Study To Determine The Pharmacokinetics Of Sulfasalazine In Children With Juvenile Idiopathic Arthritis
  “Study terminated on 13 April 2016 for business reasons. No safety and/or efficacy concerns contributed to the termination of the study” (83% match in meaning)
• Liver Transplantation With Tregs at UCSF
  “The study was terminated by the Sponsor prior to any participants receiving the investigational product.” (82% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.