Autopsy report · NCT03764774

A Study of LY3463251 in Healthy Participants

“Trial was terminated due to an insufficient benefit/tolerability ratio”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 2 years before it stopped.
• 118 participants enrolled.
• Results were posted on the registry 4 years 11 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

Eli Lilly and Company

Sponsor type

Industry

Conditions

Healthy

Interventions

LY3463251; Placebo

Participants

118

Sites

1

Countries

United States

Trials that died the same way

• Endoscopic Full Thickness Resection of Gastric Subepithelial Tumors (FROST)
  “According to study protocol the trial was terminated because the recruitment of trial participants was insufficient.” (75% match in meaning)
• A Study to Learn About the Effect of Avelumab First-Line Maintenance in Canadian People With Advanced Bladder Cancer
  “The trial was terminated for strategic reasons. The decision was not based on any safety and/or efficacy concerns.” (74% match in meaning)
• A Study to Test the Effects of Nezavist at Different Doses in Healthy Adults
  “The trial was terminated early due to regulatory constraints preventing the continuation of study conduct.” (74% match in meaning)
• TAS-117 in Patients With Advanced Solid Tumors Harboring Germline PTEN Mutations
  “The Sponsor had decided to terminate this clinical trial due to an insufficient rate of accrual of patients.” (74% match in meaning)
• Study of Inlexisertib (DCC-3116) in Participants With RAS/MAPK Pathway Mutant Solid Tumors
  “Trial terminated due to business decision, not based on any safety or efficacy concerns.” (73% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.