Autopsy report · NCT03745326

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients

“Study was closed due to lack of accrual and study outcomes overlapped with another protocol's eligibility.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 6 months before it started.
• Ran for about 3 years 3 months before it stopped.
• 5 participants enrolled.
• Results were posted on the registry 3 years 9 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 1, Phase 2

Sponsor

National Cancer Institute (NCI)

Sponsor type

US National Institutes of Health

Conditions

Gastrointestinal Cancer; Pancreatic Cancer; Gastric Cancer; Colon Cancer; Rectal Cancer

Interventions

Cyclophosphamide; Fludarabine; Aldesleukin; anti-Kirsten rat sarcoma virus (KRAS) Glycine(G) to Aspartic Acid(D) substitution at codon 12 peripheral blood lymphocytes (PBL); EKG; CT

Participants

5

Sites

1

Countries

United States

Trials that died the same way

• COVID-19 Booster Vaccine in Autoimmune Disease Non-Responders
  “The study was closed due to continued enrollment hurdles.” (79% match in meaning)
• Intensity Modulated Radiation Therapy (IMRT) for Patients With Rectal Cancer
  “The study was closed to enrollment due to slow accrual.” (78% match in meaning)
• A Phase II Trial of the DNA Methyl Transferase Inhibitor, Guadecitabine (SGI-110), in Children and Adults With Wild Type GIST,Pheochromocytoma and Paraganglioma Associated With Succinate Dehydrogenase Deficiency and HLRCC-associated Kidney Cancer
  “Study closed to enrollment due to low accrual.” (77% match in meaning)
• A Study of Alectinib in RET-rearranged Non-small Cell Lung Cancer or RET-mutated Thyroid Cancer
  “Study closed due to slow accrual and lack of efficacy.” (77% match in meaning)
• A Supportive Care Intervention for Older Caregivers of Older Adults with Advanced Cancer
  “Study has been closed to accrual earlier than anticipated and will not resume.” (76% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.