Autopsy report · NCT03590652

Daratumumab, Ixazomib, Pomalidomide, and Dexamethasone as Salvage Therapy in Relapsed/Refractory Multiple Myeloma

“The trial met its primary endpoint.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 4 months before it started.
• Ran for about 6 years 9 months before it stopped.
• 23 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

University of California, San Diego

Sponsor type

University, hospital or other

Conditions

Relapsed/Refractory Multiple Myeloma

Interventions

Ixazomib; Pomalidomide; Dexamethasone; Daratumumab-Hyaluronidase-Fihj@1,800 Mg-30,000 Unit/15 mL@SUBCUT@VIAL (ML)

Participants

23

Sites

4

Countries

United States

Trials that died the same way

• The Impact of IVIG Treatment on Critical Illness Polyneuropathy and/or Myopathy in Patients With MOF and SIRS/Sepsis
  “The trial was terminated early due to futility in reaching the primary endpoint.” (80% match in meaning)
• Study to Determine the Efficacy of Uproleselan (GMI-1271) in Combination With Chemotherapy to Treat Relapsed/Refractory Acute Myeloid Leukemia
  “Trial failed to meet primary endpoint.” (80% match in meaning)
• An Efficacy and Safety Study of Lanabecestat (LY3314814) in Early Alzheimer's Disease
  “An independent assessment concluded the trial was not likely to meet the primary endpoint upon completion and therefore, trial stopped for futility” (73% match in meaning)
• Ibrutinib lead-in Followed by Venetoclax Plus Ibrutinib in Patients With RR CLL
  “The board decision has been made to conclude the trial ahead of schedule. The primary endpoint has been successfully achieved and published, and funding was secured to support these three years of followup.” (69% match in meaning)
• Study to Assess LX201 for Prevention of Corneal Allograft Rejection or Graft Failure in Subjects Who Have Experienced One or More Rejection Episodes Following Penetrating Keratoplasty
  “The primary efficacy endpoint was not met” (67% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.