Autopsy report · NCT03504501

Synaptic Plasticity and Cognitive Function in RASopathies

“The study has been terminated prematurely due to recruitment difficulties. Current status: recruitment stopped and cleaning of the database is ongoing.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 11 months before it started.
• Ran for about 4 years 7 months before it stopped.
• 16 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Technical University of Munich

Sponsor type

University, hospital or other

Conditions

Impaired Synaptic Plasticity; Impaired Cognition

Interventions

Lovastatin; Lamotrigine

Participants

16

Sites

1

Countries

Germany

Trials that died the same way

• Safety and Tolerability of Clobazam as Adjunctive Therapy in Paediatric Patients Aged ≥1 to ≤16 Years With Dravet Syndrome
  “The study was terminated due to recruitment challenges” (86% match in meaning)
• Early Versus Late Amniotomy Following EAB Cervical Ripening
  “Study was terminated due to difficulties in recruitment” (84% match in meaning)
• Alfuzosin Versus Placebo in Acute Urinary Retention
  “The study was early terminated due to slow and difficult recruitment” (83% match in meaning)
• THromboprophylaxis In Sickle Cell Disease With Central Venous Catheters (THIS)
  “Study terminated due to slow recruitment.” (82% match in meaning)
• Safety, Tolerability and Pharmacodynamics of AP214 Acetate in Patients Undergoing Cardiac Surgery
  “The study was terminated due to a considerably lower recruitment rate than anticipated” (82% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.