Autopsy report · NCT03117361

Trial of Plitidepsin (Aplidin®) in Combination With Bortezomib and Dexamethasone in Multiple Myeloma Patients Double Refractory to Bortezomib and Lenalidomide

“PharmaMar has decided to end this study due to the slow recruitment rate of the trial”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 1 year 3 months before it stopped.
• 10 participants enrolled.
• Results were posted on the registry 2 years 4 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

PharmaMar

Sponsor type

Industry

Conditions

Multiple Myeloma

Interventions

plitidepsin; Bortezomib; Dexamethasone

Participants

10

Sites

13

Countries

France, Italy, Spain

Trials that died the same way

• Effect of Citalopram on Chest Pain in Patients With Functional Chest Pain
  “The clinical trial has ended prematurely due to low patient recruitment” (73% match in meaning)
• Study of Intraparenchymal Therapy as Adjunct Therapy in Patients With Recurrent, Resectable Glioblastoma Multiforme.
  “The decision to terminate the trial was based on the slow rate of recruitment across the programme of studies” (73% match in meaning)
• Evaluation of the Clinical Benefit of a Transmitter for Contralateral Routing of Signals (CROS)
  “This clinical trial has been early terminated due to recruiting issues of the calculated sample size.” (71% match in meaning)
• Metformin in Assisted Reproduction-MET-AR-study
  “Slow patient recruitment and expiry of study medication(aug2009)” (70% match in meaning)
• Stop Exogenous Allergic Alveolitis (EAA) in Childhood
  “After several years of recruitment only 4 patients were included. Study timelines for study completition too long. Decided to terminate trial.” (70% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.