Autopsy report · NCT03081117

Intranasal Insulin for the Treatment of HAND

“On 3/15/2020 study visits were suspended due to COVID-19 pandemic. With safety concerns surrounding COVID-19 and difficulty recruiting, the investigators decided to close enrollment 10/16/2020 after interim data were reviewed by the DSMB and NIH.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 5 months before it started.
• Ran for about 3 years 2 months before it stopped.
• 21 participants enrolled.
• Results were posted on the registry 9 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 1, Phase 2

Sponsor

Johns Hopkins University

Sponsor type

University, hospital or other

Conditions

HIV Dementia; HIV-Associated Cognitive Motor Complex

Interventions

Insulin, intranasal; Placebo, intranasal

Participants

21

Sites

1

Countries

United States

Trials that died the same way

• Emory Latino Diabetes Education Program
  “Enrollment and study activities were suspended in March 2020 due to the COVID-19 pandemic and re-opening the study was delayed pending additional funding. The study was ultimately terminated in January of 2026 due to lack of funding.” (86% match in meaning)
• A Study of Pleiotropic Pioglitazone Effects on the Alcoholic Lung (APPEAL Study)
  “Study was suspended in 2020 due to COVID-19 pandemic as a result of recruitment challenges and the inability to conduct all study procedures (e.g., bronchoscopy) per protocol. In late 2021 the decision was made to not re-open the study.” (83% match in meaning)
• Impact of Cigarette and E-cigarette Flavors on Adult Smoking Behavior
  “Study enrollment was temporarily paused in 2020 due to COVID-19. Study was closed without further enrollment in 2022.” (81% match in meaning)
• A Safety and Tolerability Study of ILB® in Patients With Amyotrophic Lateral Sclerosis (ALS)
  “Study initially suspended due to COVID-19 Pandemic- treatment stopped - never reopened to recruitment..” (80% match in meaning)
• Improving Health Behaviors for Pediatric Cancer Survivors
  “Study recruitment of new participants was suspended during 2020 due to the Covid-19 pandemic.” (79% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.