Autopsy report · NCT02986698

In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM)

“Enrollment ended early due to interim data suggesting a lack of efficacy. Interim data did demonstrate that IUHSCT was safe and well tolerated, but the PI and DSMB agreed that enrollment should not continue under the current treatment protocol.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 10 months before it started.
• Ran for about 7 years 3 months before it stopped.
• 6 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

University of California, San Francisco

Sponsor type

University, hospital or other

Conditions

Alpha Thalassemia Major; Hemoglobinopathy; With Thalassemia; Hemoglobinopathies; Fetal Anemia; Fetal Hydrops; Alpha; Thalassemia

Interventions

in utero hematopoietic stem cell transplantation

Participants

6

Sites

1

Countries

United States

Trials that died the same way

• Heliox-Powered Albuterol Therapy in the Treatment of Children Admitted With Acute Asthma Exacerbation
  “Study was stopped after interim analysis and slow enrollment.” (62% match in meaning)
• Treatment Resistance Following Anti-cancer Therapies
  “Study terminated due to lack of enrollment that has been compounded by the global COVID-19 pandemic. There were no safety and/or efficacy concerns involved in the decision to stop enrollment.” (61% match in meaning)
• Omission of Surgery in Clinically Low-risk HER2positive Breast Cancer With High HER2 Addiction and a Complete Response Following Standard Anti-HER2-based Neoadjuvant Therapy
  “The study was prematurely halted primarily due to low patient accrual. Despite efforts to optimize recruitment, the enrollment rate remained insufficient to meet the predefined targets, and continuation was deemed unfeasible” (61% match in meaning)
• RECELL to Promote Healing Following Carbon Dioxide (CO2) Laser Treatment in Cosmetic Patients
  “Study halted prematurely and will not resume; participants are no longer being examined or receiving intervention. PI decided to terminate due to slow enrollment.” (60% match in meaning)
• The Role of Osteopathic Manipulative Medicine in Recovery From Concussions
  “Due to lower than anticipated enrollment number, this study was stopped.” (59% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.