Autopsy report · NCT02954406

A Study of TAK-659 in Combination With Bendamustine (+/-Rituximab), Gemcitabine, Lenalidomide, or Ibrutinib for the Treatment of Participants With Advanced Non-Hodgkin Lymphoma

“Business decision, insufficient enrollment, no safety or efficacy concerns.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 4 months before it started.
• Ran for about 3 years 5 months before it stopped.
• 43 participants enrolled.
• Results were posted on the registry 1 year 7 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

Millennium Pharmaceuticals, Inc.

Sponsor type

Industry

Conditions

Lymphoma, Non-Hodgkin

Interventions

TAK-659; Bendamustine; Rituximab; Gemcitabine; Lenalidomide; Ibrutinib

Participants

43

Sites

13

Countries

Canada, United States

Trials that died the same way

• MLN1117 in Combination With Docetaxel, Paclitaxel, and Other Investigational Anticancer Agents to Treat Participants With Gastric and Gastroesophageal Adenocarcinoma
  “Business Decision; No Safety Or Efficacy Concerns.” (84% match in meaning)
• Study of the Efficacy and Safety of Parsaclisib in Participants With Primary Warm Autoimmune Hemolytic Anemia
  “A business decision was made to discontinue further enrollment. There were no safety concerns that contributed to this decision.” (81% match in meaning)
• Efficacy and Safety of Azilsartan Medoxomil Used in Combination With Metformin in Participants With Hypertension and Diabetes
  “Business Decision; No Safety Or Efficacy Concerns. (See below)” (78% match in meaning)
• EnligHTN IV Trial - Multicenter Sham-controlled RCT of Renal Denervation for Hypertension
  “There were no safety or effectiveness concerns. There were concerns about completing enrollment due to a competitive device's potential approval.” (76% match in meaning)
• Study of ADI-PEG 20 or Placebo Plus Gem and Doc in Previously Treated Subjects With Leiomyosarcoma (ARGSARC)
  “Lack of Efficacy, no safety concern.” (75% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.