Autopsy report · NCT02946580

Naloxegol for the Prevention of Constipation in Postoperative Spinal Surgery Patients

“Slow recruitment and inability to extend funding.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 3 months before it started.
• Ran for about 1 year 1 month before it stopped.
• 53 participants enrolled.
• Results were posted on the registry 1 year 7 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 4

Sponsor

Massachusetts General Hospital

Sponsor type

University, hospital or other

Conditions

Constipation

Interventions

MOVANTIK™ (naloxegol); Sugar Pill

Participants

53

Sites

1

Countries

United States

Trials that died the same way

• Cognitive Checking Intervention for Maladaptive Beliefs About Memory
  “Funding used up; recruitment slow.” (86% match in meaning)
• Allogeneic Human Mesenchymal Stem Cells (hMSCs) Infusion in Patients With Treatment Resistant Depression
  “Difficulty in recruitment and funding.” (82% match in meaning)
• Swiss Multi-centre, Randomized, Placebo Controlled Trial of Pregabalin for Prevention of Persistent Pain in High Risk Patients Undergoing Breast Cancer Surgery
  “insufficient funding and recruitment” (81% match in meaning)
• Reach Out and Read Arabic to Promote Arabic Literacy in Toddlers
  “Poor recruitment and lack of funding” (80% match in meaning)
• Prophylactic Use of Postpartum Sertraline to Prevent Postpartum Depression
  “Low recruitment, completion of funding cycle” (80% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.