Autopsy report · NCT02931253

Metformin as an Upstream Therapy in Atrial Fibrillation

“Recruitment issue: Enrollment expectation not met”

The sponsor’s own words in the registry.

Life of this trial

• Registered 6 months before it started.
• Ran for about 1 year 3 months before it stopped.
• 6 participants enrolled.
• Results were posted on the registry 1 year 11 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

The Guthrie Clinic

Sponsor type

University, hospital or other

Conditions

Atrial Fibrillation

Interventions

Metformin

Participants

6

Sites

1

Countries

United States

Trials that died the same way

• Randomized Trial Comparing N of 1 Trials to Standard Practice to Improve Adherence to Statins in Patients With Diabetes
  “insufficient recruitment/enrollment” (78% match in meaning)
• Vaginal Dehydroepiandrosterone (DHEA) in Postmenopausal Breast Cancer Survivors on Aromatase Inhibitors
  “Low recruitment/enrollment” (73% match in meaning)
• QuiremSpheres Observational Study
  “did not meet planned recruitment expectations with a slow recruitment rate” (72% match in meaning)
• Study of the Impact of Non-pharmacological Techniques on Cognitive Complaints in Cancer Patients
  “Problems with recruitment” (71% match in meaning)
• Ultrasound and Endometrial Hyperplasia
  “enrollment of participants has halted prematurely; difficulty with recruitment” (70% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.