Atrial Fibrillation

Why trials studying Atrial Fibrillation stopped, in this sample of ClinicalTrials.gov.

38 stopped trials with a clear reason; 95% ended for non-scientific reasons.

Trials

• Precision Ablation For Pulmonary Vein Isolation: Targeting Pulmonary Vein Myocardial Sleeves (PVMS) With Omnipolar Mapping Technology
  NCT06701292 · WITHDRAWN · slow accrual
  “lack of recruitment after technological advances replaced the study procedure.”
• SmartWatch ECG Evaluation Trial I
  NCT05942274 · WITHDRAWN · manufacturing supply
  “The manufacturer who was to provide the study devices decided not to do so.”
• Post Intensive Care Unit Atrial Fibrillation
  NCT05860894 · TERMINATED · slow accrual
  “Insufficient recruitment”
• Efficacy Rate of Unipolar Polarity Switch for Lesion Assessment in Pulmonary Vein Isolation
  NCT05464537 · TERMINATED · funding business
  “Company which provides funding is closed”
• Left Atrial Appendage Closure With WATCHMAN FLX Device in Recurrent Gastrointestinal Bleeding: The GI-FLX Registry
  NCT06052358 · TERMINATED · funding business
  “The study has been closed by the Sponsor.”
• Anticoagulation Therapy Timing in Atrial Fibrillation After Acute and Chronic Subdural Hematoma
  NCT05472766 · TERMINATED · logistics pi
  “Study terminated due to logistical challenges in conducting the trial.”
• Semaglutide for the Reduction of Arrhythmia Burden in Overweight AF Patients
  NCT04885634 · WITHDRAWN · funding business
  “Not received funding.”
• Antiorbital Calcium in Chronic Conditions
  NCT05302713 · WITHDRAWN · slow accrual
  “No participants were enrolled”
• Effective Conversion of Individuals at Risk
  NCT05112757 · TERMINATED · slow accrual
  “Very low recruitment success and all recruitment options were exhausted”
• Oral Amiodarone for Acute Cardioversion of Atrial Fibrillation Study
  NCT04594746 · TERMINATED · slow accrual
  “we couldn't recruit enough participants”
• Assessment of Intravenous Rate Control Response in Atrial Fibrillation Trial (AIRCRAFT)
  NCT04234477 · WITHDRAWN · slow accrual
  “The study was not IRB approved and there were anticipated challenges in recruiting participants.”
• Novel Methods for Characterizing Patients With Post-operative Atrial Fibrillation Secondary to Abdominal Surgery
  NCT04090918 · WITHDRAWN · slow accrual
  “It was not possible to ensure sufficient recruitment of patients to complete the study.”
• Continuous Data Collection and Analysis for Stroke Prevention Using a Wearable Sensor
  NCT03441022 · WITHDRAWN · logistics pi
  “Unable to obtain equipment from Sponsor to be able to proceed with the study.”
• His-pacing and AV-node Ablation vs. Pulmonary Vein Isolation for Atrial Fibrillation
  NCT04512586 · TERMINATED · slow accrual
  “Recruitment too slow. Unrealistic to finish study with full inclusion cohort.”
• Posterior Wall And Left Atrial Appendage Empiric Electrical Isolation for Non-Paroxysmal Atrial Fibrillation
  NCT04216667 · TERMINATED · slow accrual
  “Insufficient enrollment”
• Impact of the Information Follow-up Given to Patients on Their Disease Understanding and Therapeutic Adherence in Patients Under Direct Oral Anticoagulants and With Atrial Fibrillation in a Cardiology Department
  NCT03645564 · TERMINATED · logistics pi
  “Recruitment incomplete due to COVID”
• Renal Nerve Denervation After Pulmonary Vein Isolation for Persistent Atrial Fibrillation
  NCT03246568 · TERMINATED · funding business
  “no funding to purchase study device”
• Proper Extent of Maze Intercaval Lesion
  NCT03091205 · WITHDRAWN · funding business
  “Unable to obtain funding source”
• Handheld ECG Tracking of In-hOspital Atrial Fibrillation
  NCT03197090 · TERMINATED · slow accrual
  “poor patient recruitment and limited resources”
• Does VoltagE Guided Additional Ablation Improve Procedural Outcome of Atrial Fibrillation Ablation?
  NCT03377751 · TERMINATED · slow accrual
  “Majority of enrolled patients have withdrawn.”
• My Research Legacy Pilot Study
  NCT02958098 · TERMINATED · funding business
  “Sponsor withdrew funding”
• Catheter Ablation vs. Medical Therapy in Congested Hearts With AF
  NCT02686749 · TERMINATED · slow accrual
  “unable to reach enrollment goal”
• Effect of Pradaxa vs Warfarin on Bone Mass and Bone Turnover Markers
  NCT02791555 · TERMINATED · slow accrual
  “Study was terminated early due to low enrollment numbers.”
• Use of a High Density Mapping System to Complete Wide Area Circumferential Ablation of the Pulmonary Veins and Avoid Ostial Segmental Ablation
  NCT02917044 · TERMINATED · slow accrual
  “Recruitment issues due to competing studies. Higher than expected PVI on first pass. Sample would have to be increased which was not feasible.”
• Frontal Cognitive Control Functions Before and After Percutaneous Catheter Procedures in Treatment of Atrial Fibrillation
  NCT02306460 · TERMINATED · logistics pi
  “Changes in personnel”
• Left Atrial Appendage Occlusion vs. Usual Care in Patients With Atrial Fibrillation and Severe Chronic Kidney Disease
  NCT02039167 · TERMINATED · slow accrual
  “The recruitment rate was very poor. The study was stopped by amendment on 2015-08-28.”
• Comparison of Oxygen Interventions and Defibrillator Efficiency
  NCT02317029 · TERMINATED · safety
  “A major adverse event occured (pulsed biphasic waveform arm).”
• nMARQ™ Pulmonary Vein Isolation System for the Treatment of Paroxysmal Atrial Fibrillation
  NCT01824394 · TERMINATED · funding business
  “Business Decision”
• Dabigatran Versus Warfarin Anticoagulation Before and After Catheter Ablation for the Treatment of Atrial Fibrillation
  NCT01607359 · WITHDRAWN · funding business
  “Withdrawn: It was decided not to proceed with the study at this time.”
• Atrial Fibrillation Progression Trial
  NCT01570361 · TERMINATED · funding business
  “The sponsor decided to terminate the study early due to enrolment not proceeding in accordance with expectations, independently from the study outcome.”
• Permanent Atrial fibriLLAtion Outcome Study Using Dronedarone on Top of Standard Therapy
  NCT01151137 · TERMINATED · safety
  “The study was stopped because of safety concerns”
• PAF-HEFT (Permanent Atrial Fibrillation in Heart Failure Trial)
  NCT00839566 · TERMINATED · slow accrual
  “Number of eligible patients too small.”
• Pivotal Clinical Study of Endoscopic Ablation for Atrial Fibrillation (AF) in Patients That Have Failed Drugs
  NCT00477230 · TERMINATED · funding business
  “Study terminated based on decision of Sponsor.”
• Prophylactic Pulmonary Vein Isolation Study
  NCT00587899 · TERMINATED · slow accrual
  “enrollment has been lower than anticipated due to growth in the minimally invasive mitral valve repair practice.”
• A Prospective Multi Centre Trial on Bipolar Radiofrequency Ablation of Atrial Fibrillation
  NCT00184249 · WITHDRAWN · funding business
  “Collaborators did not enter patients into the study”
• Atrial Tissue Banking: Atrial Tissue Obtained From Patients Undergoing Heart Surgery
  NCT00248274 · TERMINATED · slow accrual
  “Staffing and departmental changes at our site made it difficult to enroll subjects.”
• Dual Chamber Versus Single Chamber Cardiac Pacing in People 80 Years of Age and Older
  NCT00116987 · TERMINATED · slow accrual
  “Unable to recruit adequate number of participants in required time frame.”
• Ventricular Rate Regularization for Improved Quality of Life in Patients With CHF and AF
  NCT00583921 · WITHDRAWN · slow accrual
  “no subjects enrolled”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.