Autopsy report · NCT02725372

Clinical Study of Pulsed, Inhaled Nitric Oxide Versus Placebo in Symptomatic Subjects With PAH

“Trial stopped for futility”

The sponsor’s own words in the registry.

Life of this trial

• Registered 3 months before it started.
• Ran for about 2 years 4 months before it stopped.
• 207 participants enrolled.
• Results were posted on the registry 4 years 5 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Bellerophon Pulse Technologies

Sponsor type

Industry

Conditions

Pulmonary Arterial Hypertension

Interventions

Inhaled Nitric Oxide 75 mcg/kg IBW/hr; Placebo

Participants

207

Sites

109

Countries

Australia, Austria, Belgium, Canada, Colombia, Croatia, Czechia, France, Germany, Israel, Italy, Netherlands and more

Trials that died the same way

• Docetaxel With or Without a Phytochemical in Treating Patients With Breast Cancer
  “The trial was stopped for futility in view of the results of the anticipated analysis” (81% match in meaning)
• Stanford Accelerated Recovery Trial (START)
  “Trial met futility stopping point” (80% match in meaning)
• Folate Receptor Alpha Peptide Vaccine With GM-CSF Versus GM-CSF Alone in Patients With Platinum Sensitive Ovarian Cancer
  “Futility analysis did not support continuation of the trial” (78% match in meaning)
• Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM)
  “This trial was terminated following a futility analysis confirming futility of continuing the study” (77% match in meaning)
• An Efficacy and Safety Study of Lanabecestat (LY3314814) in Early Alzheimer's Disease
  “An independent assessment concluded the trial was not likely to meet the primary endpoint upon completion and therefore, trial stopped for futility” (75% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.