Autopsy report · NCT02702115

Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-318 in Subjects With MPS I

“All three subjects dosed in the study have rolled over to the Long-Term Follow-up Study IVPRP-LT01 (NCT04628871)”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 year 3 months before it started.
• Ran for about 4 years 5 months before it stopped.
• 3 participants enrolled.
• Results were posted on the registry 1 year 3 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 1, Phase 2

Sponsor

Sangamo Therapeutics

Sponsor type

Industry

Conditions

MPS I

Interventions

SB-318

Participants

3

Sites

1

Countries

United States

Trials that died the same way

• Fecal Transplant for MDR Pathogen Decolonization
  “This observational study has been transitioned to a clinical trial and is now registered at (NCT04181112).” (64% match in meaning)
• Study to Evaluate the Safety of AT2220 (Duvoglustat) in Pompe Disease
  “Per protocol, 3 sequential dose cohorts were planned. Study discontinued by Sponsor based upon serious adverse events in first 2 of 3 participants in Cohort 1.” (64% match in meaning)
• An Open Label Extension Study of STX209 in Subjects With Autism Spectrum Disorders
  “all active subjects were rolled into study 209AS209/NCT01706523” (64% match in meaning)
• Safety and Efficacy Evaluation of Bosutinib Plus Atezolizumab in Newly Diagnosed Chronic Leukemia Adult Patients
  “The study has been prematurely terminated due to the onset of 2 dose limiting toxicities in 2 patients.” (62% match in meaning)
• Vaping High vs. Low Nicotine E-Liquid
  “Please see NCT04053868 for the current version of this study” (60% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.