Autopsy report · NCT02654730

Evaluation of the Safety of Primaquine in Combination With Dihydroartemisinin-piperaquine in G6PD Deficient Males in The Gambia

“Enrollment took longer than anticipated; it was financially and logistically impossible to recruit the final cohort (G6PDd 0.4mg/kg PQ).”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 1 year before it stopped.
• 61 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2, Phase 3

Sponsor

London School of Hygiene and Tropical Medicine

Sponsor type

University, hospital or other

Conditions

Malaria

Interventions

Dihydroartemisinin-piperaquine (DHAP) administered to G6PD deficient; Dihydroartemisinin-piperaquine (DHAP) + 0.25 mg/kg primaquine administered to G6PD deficient; Dihydroartemisinin-piperaquine (DHAP) + 0.4 mg/kg primaquine administered to G6PD deficient; Dihydroartemisinin-piperaquine (DHAP) + 0.25 mg/kg primaquine administered to G6PD normal; Dihydroartemisinin-piperaquine (DHAP) + 0.4 mg/kg primaquine administered to G6PD normal

Participants

61

Sites

1

Countries

The Gambia

Trials that died the same way

• Omission of Surgery in Clinically Low-risk HER2positive Breast Cancer With High HER2 Addiction and a Complete Response Following Standard Anti-HER2-based Neoadjuvant Therapy
  “The study was prematurely halted primarily due to low patient accrual. Despite efforts to optimize recruitment, the enrollment rate remained insufficient to meet the predefined targets, and continuation was deemed unfeasible” (64% match in meaning)
• Support and Rehabilitation Protocol for Non Metastatic Breast Cancer Patients in Complete Remission After Chemotherapy
  “Enrollment lasted longer than expected and expected number of patients could not be matched in time.” (62% match in meaning)
• Prospective Study of the sensiTVT
  “The recruitment proceeded much slower than expected. The planned number of patients could not be reached within the planned time.” (60% match in meaning)
• Observational Study of Fostamatinib as Second Line Therapy in Adult Patients With Immune Thrombocytopenia (ITP) and Insufficient Response to a Prior Therapy
  “met minimum enrollment goal, however, enrollment was slow due to the pandemic, therefore, the study was terminated” (59% match in meaning)
• Non-invasive Improvement of Buttocks With Magnetic Device
  “It wasn't possible to recruit the desired number of patients.” (58% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.