Autopsy report · NCT02618577

Non-vitamin K Antagonist Oral Anticoagulants in Patients With Atrial High Rate Episodes

“following a recommendation from the data safety and monitoring board due to safety concerns and a tendency towards futility.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 3 months before it started.
• Ran for about 6 years 11 months before it stopped.
• 2,608 participants enrolled.
• Results were posted on the registry 2 years 1 month after it ended.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Atrial Fibrillation Network

Sponsor type

University, hospital or other

Conditions

Atrial High Rate Episodes

Interventions

Edoxaban; ASA

Participants

2,608

Sites

18

Countries

Austria, Belgium, Bulgaria, Czechia, Denmark, France, Germany, Greece, Hungary, Italy, Netherlands, Poland and more

Trials that died the same way

• High Resolution Imaging of Cerebral Vasculature by Functional Micro-Doppler Sonography During Brain Surgery
  “recommandation of the Data Safety monitoring Board” (74% match in meaning)
• The Efficacy of Enteric-coated Mycophenolate Sodium (EC-MPS) (Myfortic) in The Treatment of Relapse or Resistant Proliferative Lupus Nephritis
  “Data Safety Monitoring Board concerning of the participants' safety” (73% match in meaning)
• Methylprednisolone in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS)
  “Following a recommendation from the Data Safety Monitoring Board (DSMB).” (72% match in meaning)
• The Efficacy and Safety of REX-001 to Treat Ischemic Ulcers in Subjects With CLI Rutherford Category 5 and DM
  “Independent Data Monitoring Committee recommendation to stop due to futility” (69% match in meaning)
• Lithium in Multiple System Atrophy
  “Data Monitoring Committee decision on 22nd August 2011 for safety issues” (69% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.