Autopsy report · NCT02187029

Efficacy, Safety And Tolerability Of PF-06743649 In Gout Subjects.

“B7911002 was prematurely discontinued due to a safety concern that led to decision to terminate the study on 10 Nov 2014”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 5 months before it stopped.
• 30 participants enrolled.
• Results were posted on the registry 1 year 11 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

Pfizer

Sponsor type

Industry

Conditions

Gout

Interventions

PF-06743649; Placebo; PF-06743649; Placebo

Participants

30

Sites

4

Countries

United States

Trials that died the same way

• Safety of Rivipansel (GMI-1070) in the Treatment of One or More Vaso-Occlusive Crises in Hospitalized Subjects With Sickle Cell Disease
  “The B5201003 OLE study was terminated based on the failure of the 'parent" B5201002 study to meet its efficacy endpoints. Termination was not due to safety.” (68% match in meaning)
• A Dose Escalation Trial of PR610 Treating Patients With Solid Tumors
  “Study was prematurely discontinued due to unacceptable toxicity.” (67% match in meaning)
• Study of Brain Tumors (Tectal Tumors) Using Magnetic Resonance Imaging
  “There were technical difficulties and the study was terminated in 2008” (67% match in meaning)
• A Study Of PF-06664178 In Patients With Advanced Solid Tumors
  “The study was prematurely discontinued due to a business-related decision on 09-FEB-2016. The decision to terminate the trial was based on the overall results.” (67% match in meaning)
• A Study to Assess the Safety, Tolerability and Effectiveness of MT-0814 for the Treatment of Age-related Macular Degeneration
  “The study terminated for safety reasons” (66% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.