Autopsy report · NCT02050815

MEK162 in Healthy Subjects With Normal Hepatic Function and Subjects With Impaired Hepatic Function

“The Sponsor is terminating the study because the primary objective was achieved after 5 of the 6 subjects were assessed in the final cohort.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 months before it started.
• Ran for about 2 years 5 months before it stopped.
• 27 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

Array Biopharma, now a wholly owned subsidiary of Pfizer

Sponsor type

Industry

Conditions

Hepatic Impairment

Interventions

MEK162

Participants

27

Sites

5

Countries

United States

Trials that died the same way

• A Phase 2a Pharmacodynamic Study of TAK-448 in Participants With Hypogonadotropic Hypogonadism
  “Sponsor decision to terminate the study because the study did not achieve the primary efficacy objective.” (78% match in meaning)
• Study of RP-6306 With FOLFIRI in Advanced Solid Tumors
  “Sponsor decided to terminate the study” (76% match in meaning)
• Study of Viziatek ISL™ Refractive Phakic Intra Sulcus Lens for Refraction Adjustment in Blind Volunteers
  “Sponsor decision to terminate the study” (75% match in meaning)
• A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of LB4330 in Patients With Advanced Solid Tumors（MEETCD8-001）
  “Due to adjustments in the sponsor's development strategy, it has been decided to terminate the study.” (75% match in meaning)
• A Study of ABP 215 Versus Bevacizumab in Chinese Subjects With Advanced Non-Squamous Non-Small Cell Lung Cancer
  “Sponsor decision to early terminate the study” (74% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.