Autopsy report · NCT01921985

Terlipressin Administration in Patients Undergoing Major Liver Resection

“Interim analysis revealed that no statistical difference will be identified after inclusion of the patient cohort as foreseen in the sample size calculation”

The sponsor’s own words in the registry.

Life of this trial

• Registered 3 months before it started.
• Ran for about 4 years 4 months before it stopped.
• 150 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Insel Gruppe AG, University Hospital Bern

Sponsor type

University, hospital or other

Conditions

Liver Resection; Liver Failure

Interventions

Terlipressin; Placebo

Participants

150

Sites

1

Countries

Switzerland

Trials that died the same way

• Randomized, Multi-center, Open-label, Study of PR104 Versus PR104/Docetaxel in Non-Small Cell Lung Cancer (NSCLC)
  “Interim analysis indicated low probability of clinically significant result” (62% match in meaning)
• Efficacy Study of Polyunsaturated Fatty Acids in Children and Adolescents With Attention Deficit/ Hyperactivity Disorder
  “The sample size of the planned interims analysis was achieved” (62% match in meaning)
• Acupuncture and Post-Surgical Wound Healing
  “No difference in primary outcomes at interim analysis.” (60% match in meaning)
• Study of Taxoprexin Injection vs. Dacarbazine in Patients With Metastatic Malignant Melanoma
  “Interim analysis determined that the futility boundary had been crossed and there was no reasonable prospect that statistical significance would be achieved if patient accrual continued” (60% match in meaning)
• Optimal Surgical Treatment Of Fulminant Clostridium Difficile Colitis
  “Numer of eligible patients markedly decreased since the initiation of the study.” (59% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.