Autopsy report · NCT00087776

Study of Taxoprexin Injection vs. Dacarbazine in Patients With Metastatic Malignant Melanoma

“Interim analysis determined that the futility boundary had been crossed and there was no reasonable prospect that statistical significance would be achieved if patient accrual continued”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 year 7 months after it had already started.
• Ran for about 4 years 11 months before it stopped.
• 393 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

American Regent, Inc.

Sponsor type

Industry

Conditions

Malignant Melanoma

Interventions

Taxoprexin; Dacarbazine

Participants

393

Sites

1

Countries

United States

Trials that died the same way

• Comparison of Direct Laryngoscopy, Truview EVO2 and Glidescope in Pediatric Patients
  “The study was stopped for futility at the first interim analysis” (74% match in meaning)
• Tissue Adhesive vs. Sterile Strips After Cesarean Delivery
  “Based on results of an interim analysis, the study was halted for futility” (74% match in meaning)
• CONvalescent Plasma for Hospitalized Adults With COVID-19 Respiratory Illness (CONCOR-1)
  “Study was terminated after the planned interim analysis as the pre-defined futility threshold was met” (73% match in meaning)
• Microdosed Atropine 0.1% and 0.01% Ophthalmic Solutions for Reduction of Pediatric Myopia Progression
  “Interim Analysis reviewed by Data Monitoring Committee indicated futility” (72% match in meaning)
• Trial Investigating the Efficacy and Safety of SCH 900435 (Org 25935) in Relapse Prevention in Participants With Alcohol Dependence (P05718)
  “Based on the outcome of a planned interim analysis, the study was stopped early due to futility.” (72% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.