Autopsy report · NCT01667107

A Pharmacokinetic Analysis of Posaconazole in Lung Transplant Recipients (MK-5592-105)

“Study terminated due to an unfavorable risk-benefit analysis”

The sponsor’s own words in the registry.

Life of this trial

• Registered 5 months before it started.
• Ran for about 1 year before it stopped.
• 26 participants enrolled.
• Results were posted on the registry 1 year after it ended.

Vital statistics

Status

Terminated

Phase

Phase 4

Sponsor

Merck Sharp & Dohme LLC

Sponsor type

Industry

Conditions

Fungal Infection

Interventions

Posaconazole; Calogen®

Participants

26

Trials that died the same way

• Safety and Tolerability Study of AZD7762 in Combination With Gemcitabine
  “Termination of the study was made after a full review of program data and assessment of the current risk-benefit profile.” (80% match in meaning)
• An Evaluation of the Erchonia Laser As a Non-Invasive Treatment to Improve the Appearance of Skin Laxity
  “The study was terminated early due to sponsor decision unrelated to safety or efficacy findings” (79% match in meaning)
• A Clinical Study to Test How Effective and Safe GLPG1690 is for Subjects With Idiopathic Pulmonary Fibrosis (IPF) When Used Together With Standard of Care
  “The benefit-risk profile no longer supports continuing the study” (78% match in meaning)
• Study To Determine The Pharmacokinetics Of Sulfasalazine In Children With Juvenile Idiopathic Arthritis
  “Study terminated on 13 April 2016 for business reasons. No safety and/or efficacy concerns contributed to the termination of the study” (78% match in meaning)
• A Study to Assess the Safety, Tolerability and Effectiveness of MT-0814 for the Treatment of Age-related Macular Degeneration
  “The study terminated for safety reasons” (78% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.